3,4-(Methylenedioxy)mandelic acid
3,4-(Methylenedioxy)mandelic acid (CAS 27738-46-1), with the empirical formula C9H8O5 and molecular weight 196.16, is a valuable organic building block. This carboxylic acid derivative is recognised for its utility in synthetic organic chemistry, particularly as a precursor in the preparation of complex natural products and pharmaceutical intermediates. Its structure incorporates both a benzodioxole ring and an alpha-hydroxy acid moiety, offering diverse reactivity for chemical transformations.
- IUPAC
- α-Hydroxy-1,3-benzodioxole-5-acetic acid
- Synonyms
- α-Hydroxy-1,3-benzodioxole-5-acetic acid2-(1,3-Benzodioxol-5-yl)-2-hydroxyacetic acid
Synthesis of Cephalotaxine Alkaloids
3,4-(Methylenedioxy)mandelic acid serves as a crucial starting material in the synthetic pathways leading to potent anti-cancer agents like cephalotaxine. Its specific stereochemistry and functional groups are leveraged to construct the complex molecular architecture of these natural products.
Intermediate for Harringtonine and Drupacine
This compound is employed in the laboratory synthesis of harringtonine and drupacine, which are also members of the cephalotaxine ester alkaloid family. These compounds have demonstrated significant biological activity, making their synthesis a key area of research.
Research and Development
As a versatile organic building block, 3,4-(Methylenedioxy)mandelic acid is used in academic and industrial research for developing novel synthetic methodologies and exploring new chemical entities with potential therapeutic applications.
| Molecular weight | 196.16 |
|---|---|
| Empirical formula | C9H8O5 |
| Assay | ≥98.0% |
| Application | 3,4-(Methylenedioxy)mandelic acid was used as starting reagent in the synthesis of (-)cephalotaxine, (+)harringtonine and (-)drupacine1. |
| Melting point | 158-162 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4-(Methylenedioxy)mandelic acid used for?
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3,4-(Methylenedioxy)mandelic acid is primarily used as a starting reagent in the synthesis of natural products such as cephalotaxine, harringtonine, and drupacine, which are investigated for their biological activities.
What are the CAS number and formula for 3,4-(Methylenedioxy)mandelic acid?
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The CAS number for 3,4-(Methylenedioxy)mandelic acid is 27738-46-1. Its empirical formula is C9H8O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,4-(Methylenedioxy)mandelic acid with a purity of ≥98.0%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 3,4-(Methylenedioxy)mandelic acid be handled safely?
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3,4-(Methylenedioxy)mandelic acid is a warning irritant. Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. Refer to the safety data sheet for comprehensive handling information.
Is 3,4-(Methylenedioxy)mandelic acid a controlled substance?
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The provided data does not indicate that 3,4-(Methylenedioxy)mandelic acid is a scheduled or controlled substance. However, users should always comply with local regulations regarding chemical procurement and handling.
How is this chemical shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Products are carefully packaged to ensure safe transit and compliance with international shipping regulations. Please contact us for specific export inquiries.
How can I request a sample or quote for 3,4-(Methylenedioxy)mandelic acid?
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To request a sample or obtain a quote, please contact the Tech Serve Solutions sales department via our website or directly by phone. Our team will be pleased to assist you with your chemical requirements.
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