3,4,5-Trimethoxyphenylmagnesium bromide solution
3,4,5-Trimethoxyphenylmagnesium bromide solution (CAS: 133095-91-7) is an organometallic reagent featuring a reactive Grignard species. With a molecular weight of 271.39 g/mol and supplied as a 0.5 M solution in Tetrahydrofuran (THF), it is primarily utilised as a building block in organic synthesis for the introduction of the 3,4,5-trimethoxyphenyl moiety into target molecules, particularly in pharmaceutical and fine chemical research.
- Synonyms
- 133095-91-7, (CH3O)3C6H2MgBr
Organic Synthesis Reagent
This Grignard reagent serves as a nucleophilic source of the 3,4,5-trimethoxyphenyl group, enabling carbon-carbon bond formation with various electrophiles. It is instrumental in constructing complex molecular architectures.
Pharmaceutical Intermediate Synthesis
The 3,4,5-trimethoxyphenyl motif is present in several biologically active compounds. This reagent facilitates the efficient synthesis of potential drug candidates and related analogues during research and development.
Fine Chemical Production
Used in the development and small-scale production of specialised fine chemicals, where precise incorporation of the trimethoxyphenyl unit is required for specific material properties or functionalities.
| Molecular weight | 271.39 |
|---|---|
| Linear formula | (CH3O)3C6H2MgBr |
| Density | 0.979 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,4,5-Trimethoxyphenylmagnesium bromide solution used for?
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It is primarily used as a nucleophilic reagent in organic synthesis to introduce the 3,4,5-trimethoxyphenyl group into molecules, particularly in the development of pharmaceutical intermediates and fine chemicals.
What is the CAS number and chemical formula for this product?
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The CAS number is 133095-91-7, and the linear formula is (CH₃O)₃C₆H₂MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. We do not claim any specific pharmacopoeia grade (USP, EP, BP) unless explicitly stated in the product specifications. It is suitable for laboratory research and chemical synthesis applications.
How should 3,4,5-Trimethoxyphenylmagnesium bromide solution be handled safely?
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This compound is flammable and corrosive, reacting violently with water and potentially forming explosive peroxides. Handle with extreme care in a well-ventilated area, wearing appropriate personal protective equipment including gloves, goggles, and face shield. Avoid contact with water, acids, and oxidising agents. Store at 2-8°C.
Is this product controlled or scheduled?
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The provided data does not indicate that this chemical is a controlled or scheduled substance. However, users should always verify local regulations.
How is this chemical shipped and exported by TSS?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. This product is shipped according to international regulations for hazardous materials, ensuring safe and compliant transport worldwide. Please contact us for specific export documentation and shipping details.
How can I request a sample or quote for this product?
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To request a sample or a quote, please visit the product page on the TSS website and use the 'Request Information' or 'Add to Quote' buttons, or contact our sales team directly via email or phone.
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