3-(2-Hydroxyethyl)indole
3-(2-Hydroxyethyl)indole (CAS 526-55-6) is an organic compound with the molecular formula C10H11NO and a molecular weight of 161.20 g/mol. This indole derivative serves as a valuable reactant in the synthesis of various biologically active molecules. Its applications span the development of inhibitors for RNA polymerase II, anti-HIV agents, protein-protein interaction modulators, and ligands for specific cellular receptors, demonstrating its utility in pharmaceutical research and chemical synthesis.
- IUPAC
- 2-(3-Indolyl)ethanol,3-Indoleethanol,IEA,NSC 3884,Tryptophol
- Synonyms
- 2-(3-Indolyl)ethanol3-IndoleethanolIEANSC 3884Tryptophol
Synthesis of Pharmaceutical Intermediates
3-(2-Hydroxyethyl)indole is utilized as a key building block in the preparation of compounds with potential antitumor activities, including inhibitors of RNA polymerase II. It also serves as a precursor for synthesizing anti-HIV-1 agents.
Development of Receptor Ligands
This compound is employed in the research and development of partial agonists for the serotonin 5-HT1A receptor and A2B adenosine receptor ligands. These applications are crucial for neurological and cardiovascular drug discovery.
Enzyme Inhibitor Research
It is used in the synthesis of dual binding site acetylcholinesterase inhibitors and inhibitors of interleukine 6. These are significant targets in the study of neurodegenerative diseases and inflammatory conditions.
Protein-Protein Interaction Modulators
3-(2-Hydroxyethyl)indole is a precursor for developing inhibitors of protein-protein interactions, a growing area of therapeutic research aimed at modulating cellular signalling pathways.
| Molecular weight | 161.20 |
|---|---|
| Empirical formula | C10H11NO |
| Assay | 97% |
| Application | Reactant for preparation of:• Inhibitors of the C-terminal domain of RNA polymerase II and their antitumor activities• Anti-HIV-1 agents1• Inhibitors of Protein-Protein Interactions2• Partial agonists of the serotonin 5-HT1A receptor3• Growth hormone secretagogues4• Vascular endothelial growth factor (VEGF) inhibitors5• A2B adenosine receptor ligands6• Potential detoxification inhibitors of the crucifer phytoalexin brassinin7• Inhibitors of interleukine 68• Dual binding site acetylcholinesterase inhibitors9 |
| Melting point | 56-59 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(2-Hydroxyethyl)indole used for?
+
3-(2-Hydroxyethyl)indole is primarily used as a reactant in the synthesis of various biologically active compounds, including inhibitors of RNA polymerase II, anti-HIV agents, protein-protein interaction modulators, and ligands for cellular receptors such as serotonin 5-HT1A and A2B adenosine receptors. It is also a precursor for developing enzyme inhibitors.
What are the CAS number and formula for 3-(2-Hydroxyethyl)indole?
+
The CAS number for 3-(2-Hydroxyethyl)indole is 526-55-6, and its molecular formula is C10H11NO.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 3-(2-Hydroxyethyl)indole with an assay of 97%. We do not represent this product as USP, BP, or EP grade; it is supplied for research and industrial applications.
What are the safety considerations when handling 3-(2-Hydroxyethyl)indole?
+
Handling 3-(2-Hydroxyethyl)indole requires appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. The product has a WGK Germany rating of 3, indicating it is hazardous to water.
How is 3-(2-Hydroxyethyl)indole packed and shipped?
+
Tech Serve Solutions expertly packs and ships fine chemicals, pharmaceutical intermediates, and laboratory reagents globally. Specific packaging details for 3-(2-Hydroxyethyl)indole are available upon request.
How can I request a sample or quote for 3-(2-Hydroxyethyl)indole?
+
To request a sample or obtain a quote for 3-(2-Hydroxyethyl)indole, please contact our sales team through the website or by phone. Our team will assist you with your specific requirements.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis