(2S)-N-[(1S,2S)-2-Hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide
(2S)-N-[(1S,2S)-2-Hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide (CAS 529486-26-8) is a chiral organic compound with the molecular formula C19H22N2O2 and a molecular weight of 310.39 g/mol. It functions as a valuable reagent in asymmetric synthesis and is derived from proline. This compound is essential for chemists seeking to achieve high stereoselectivity in various chemical transformations, particularly in the development of novel pharmaceutical intermediates and fine chemicals. Stored at 2-8°C, it is supplied with an assay of ≥99% purity.
- IUPAC
- (2S,1′S, 2′S)-Pyrrolidine-2-carboxylic acid (2-hydroxy-1,2-diphenyl-ethyl)amide
- Synonyms
- 529486-26-8C19H22N2O2(2S,1′S, 2′S)-Pyrrolidine-2-carboxylic acid (2-hydroxy-1,2-diphenyl-ethyl)amide
![(2S)-N-[(1S,2S)-2-Hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide (C19H22N2O2) — chemical structure, CAS 529486-26-8; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F529486-26-8.png&w=3840&q=75)
Asymmetric Synthesis
This compound serves as a chiral auxiliary or catalyst in asymmetric synthesis, enabling the stereoselective creation of new chiral centres in organic molecules. Its structure is well-suited for inducing high enantiomeric excess in various reactions.
Organocatalysis
As a proline-based organocatalyst, it facilitates a range of organic transformations without the need for metal catalysts. This approach is increasingly favoured for its environmental benefits and selectivity.
Chiral Ligand Development
It can be employed in the synthesis of more complex chiral ligands for transition metal catalysis. The defined stereochemistry of the pyrrolidine and diamine moieties allows for precise control over catalytic processes.
Pharmaceutical Intermediate Synthesis
This reagent is instrumental in the stereocontrolled synthesis of advanced pharmaceutical intermediates, contributing to the efficient production of enantiomerically pure active pharmaceutical ingredients (APIs).
| Molecular weight | 310.39 |
|---|---|
| Empirical formula | C19H22N2O2 |
| Assay | ≥99% (HPLC) |
| Optical activity | [α]/D -25±2°, c = 2 in ethanol |
| Storage temperature | 2-8°C |
| Melting point | 127-131 °C |
Hazard statements
- H301Toxic if swallowed
- H331Toxic if inhaled
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1/PG 3 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 23/25-50 |
| Safety statements (S) | 45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is (2S)-N-[(1S,2S)-2-Hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide used for?
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This compound is primarily used as a chiral auxiliary or organocatalyst in asymmetric synthesis and for the development of chiral ligands, playing a key role in the stereoselective synthesis of complex organic molecules and pharmaceutical intermediates.
What are the CAS number and formula for this chemical?
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The CAS number is 529486-26-8, and the empirical formula (Hill notation) is C19H22N2O2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of ≥99% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should (2S)-N-[(1S,2S)-2-Hydroxy-1,2-diphenylethyl]-2-pyrrolidinecarboxamide be handled safely?
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This compound is classified as Danger with hazards including acute toxicity (oral and inhalation) and is very toxic to aquatic life (H301, H331, H400). Handling requires appropriate PPE such as eyeshields, faceshields, gloves, and P2 respirator cartridges. Avoid release to the environment. In case of exposure, seek immediate medical attention (P301 + P310, P311).
How is this product packed, shipped, and exported?
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This product is classified under UN 2811 (Toxic solid, organic, n.o.s.) with Packing Group III. As a specialist global supplier and exporter, Tech Serve Solutions ensures compliant packaging and documentation for international shipments.
How can I request a sample or quote for this chemical?
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You can request a sample or obtain a quote by contacting the Tech Serve Solutions sales team directly through our website or by calling our customer service.
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