N,N-Diethyltrimethylsilylamine
N,N-Diethyltrimethylsilylamine (CAS: 996-50-9) is an organosilicon compound with the molecular formula (C2H5)2NSi(CH3)3 and a molecular weight of 145.32 g/mol. This volatile liquid, characterized by its refractive index of n20/D 1.411, serves as a versatile building block in organic synthesis. It is primarily utilized in chemical reactions where a silylating agent or a source of diethylamine is required, contributing to the development of complex molecules.
- IUPAC
- (Diethylamino)trimethylsilane,N-(Trimethylsilyl)diethylamine,TMSDEA
- Synonyms
- (C2H5)2NSi(CH3)3(Diethylamino)trimethylsilaneN-(Trimethylsilyl)diethylamineTMSDEA

Silylating Agent
N,N-Diethyltrimethylsilylamine is employed as a silylating agent in organic chemistry. It can be used to protect hydroxyl or amine groups by introducing a trimethylsilyl (TMS) group, which can later be removed under specific conditions.
Organic Synthesis
As a building block, this compound facilitates the synthesis of various organic molecules. Its structure allows for its incorporation into more complex compounds or acts as a reagent in specific synthetic transformations.
Reagent in Nitrogen Chemistry
The compound contains a diethylamino group, making it useful in reactions involving nitrogen functionalities or as a source for introducing this group into target molecules.
| Molecular weight | 145.32 |
|---|---|
| Linear formula | (C2H5)2NSi(CH3)3 |
| Assay | 97% |
| Boiling point | 125-126 °C(lit.) |
| Density | 0.767 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.411(lit.) |
| Vapour density | >1 (vs air) |


Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 9 °C / 48.2 °F |
| Transport (UN / ADR) | UN 2733PSN1 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is N,N-Diethyltrimethylsilylamine used for?
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N,N-Diethyltrimethylsilylamine is used as a silylating agent and a building block in organic synthesis, particularly in reactions involving nitrogen functionalities.
What is the CAS number and formula for N,N-Diethyltrimethylsilylamine?
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The CAS number is 996-50-9 and the linear formula is (C2H5)2NSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies N,N-Diethyltrimethylsilylamine with an assay of 97%. We do not represent this product as USP, BP, or EP grade.
What are the main hazards associated with N,N-Diethyltrimethylsilylamine?
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N,N-Diethyltrimethylsilylamine is a highly flammable liquid and vapour (H225) and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment in a well-ventilated area.
How is N,N-Diethyltrimethylsilylamine packed and shipped?
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This chemical is packed according to international shipping regulations for hazardous materials, including UN 2733, PSN1 8(3) / PGII. TSS is a specialist global supplier and exporter.
How can I request a sample or quote for N,N-Diethyltrimethylsilylamine?
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Please contact our sales team through our website or by phone to request a sample or a quotation for N,N-Diethyltrimethylsilylamine.
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