2-(Trifluoromethyl)benzoic acid
2-(Trifluoromethyl)benzoic acid (CAS: 433-97-6), with the molecular formula CF3C6H4CO2H and a molecular weight of 190.12 g/mol, is a crucial organic building block. This carboxylic acid derivative is widely employed in chemical synthesis, particularly for creating heterocyclic compounds and in pharmaceutical research. It serves as a key intermediate in the development of novel molecules.
- IUPAC
- α,α,α-Trifluoro-o-toluic acid,2-Carboxybenzotrifluoride
- Synonyms
- α,α,α-Trifluoro-o-toluic acid2-Carboxybenzotrifluoride
Synthesis of Heterocyclic Compounds
2-(Trifluoromethyl)benzoic acid is utilised in the synthesis of various heterocyclic structures. For example, it has been used in the preparation of 1,3,4-oxadiazole derivatives.
Biochemical Research
This compound has been employed in studies investigating molecular interactions. It has been used to explore the binding of ligands to chaperone proteins like PapD and FimC through techniques such as surface plasmon resonance and NMR spectroscopy.
Organic Synthesis Intermediate
As a versatile building block, 2-(Trifluoromethyl)benzoic acid serves as a valuable intermediate in broader organic synthesis pathways, enabling the construction of complex molecules for diverse research applications.
| Molecular weight | 190.12 |
|---|---|
| Linear formula | CF3C6H4CO2H |
| Assay | 98% |
| Boiling point | 247 °C/753 mmHg(lit.) |
| Application | 2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety1. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1HNMR spectroscopy2. |
| Melting point | 107-110 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Trifluoromethyl)benzoic acid used for?
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2-(Trifluoromethyl)benzoic acid is primarily used as a building block in organic synthesis and in biochemical research, including the preparation of heterocyclic compounds and ligand binding studies.
What are the CAS number and molecular formula for 2-(Trifluoromethyl)benzoic acid?
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The CAS number for 2-(Trifluoromethyl)benzoic acid is 433-97-6, and its molecular formula is CF3C6H4CO2H.
What grade and purity does Tech Serve Solutions supply for 2-(Trifluoromethyl)benzoic acid?
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Tech Serve Solutions supplies 2-(Trifluoromethyl)benzoic acid with a purity of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2-(Trifluoromethyl)benzoic acid be handled safely?
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Handle 2-(Trifluoromethyl)benzoic acid with appropriate personal protective equipment, including a dust mask type N95, eyeshields, and gloves. Ensure good ventilation and avoid breathing dust. It is classified as a Warning substance with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335).
Does Tech Serve Solutions export 2-(Trifluoromethyl)benzoic acid?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-(Trifluoromethyl)benzoic acid.
How can I request a sample or quote for 2-(Trifluoromethyl)benzoic acid?
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To request a sample or quote for 2-(Trifluoromethyl)benzoic acid, please contact our sales team through the website or by phone.
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