2′-(Trifluoromethyl)acetophenone
2′-(Trifluoromethyl)acetophenone (CAS: 17408-14-9) is a ketone compound with the molecular formula CF<sub>3</sub>C<sub>6</sub>H<sub>4</sub>COCH<sub>3</sub> and a molecular weight of 188.15 g/mol. This chemical serves as a valuable building block in organic synthesis, particularly in the development of new chemical entities and materials. Its trifluoromethyl group imparts unique electronic properties, making it a useful intermediate for various chemical transformations.
Trifluoromethylation Reactions
2′-(Trifluoromethyl)acetophenone has been utilized in studies investigating the <i>in situ</i> generation of CuCF<sub>3</sub> for the direct substitution of chlorine atoms in aromatic substrates with a trifluoromethyl group. This highlights its role in advancing trifluoromethylation methodologies.
Organic Synthesis Intermediate
As a functionalised acetophenone derivative, this compound is a versatile building block in organic chemistry. It can be employed in a range of synthetic pathways to construct more complex molecules for pharmaceutical and materials science research.
Research and Development
The compound's specific structure, featuring both a ketone and a trifluoromethyl group on an aromatic ring, makes it a key component in exploratory chemical synthesis and methodology development within academic and industrial research settings.
| Molecular weight | 188.15 |
|---|---|
| Linear formula | CF3C6H4COCH3 |
| Assay | 99% |
| Density | 1.255 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4584(lit.) |
| Application | 2′-(Trifluoromethyl)acetophenone has been used to investigate the use of in situ generated CuCF3 for the direct substitution of chlorine by CF3 in various aromatic substrates1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 84 °C / 183.2 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2′-(Trifluoromethyl)acetophenone used for?
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2′-(Trifluoromethyl)acetophenone is used as a building block in organic synthesis, particularly in trifluoromethylation reactions and the development of new chemical entities and materials.
What are the CAS number and chemical formula for 2′-(Trifluoromethyl)acetophenone?
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The CAS number is 17408-14-9 and the linear chemical formula is CF<sub>3</sub>C<sub>6</sub>H<sub>4</sub>COCH<sub>3</sub>.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2′-(Trifluoromethyl)acetophenone with an assay of 99%. This product is intended for laboratory and research use and is not represented as USP, BP, or EP grade.
How should 2′-(Trifluoromethyl)acetophenone be handled safely?
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Based on GHS information, 2′-(Trifluoromethyl)acetophenone is a warning substance (GHS07) that may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used. Handle in a well-ventilated area.
Is 2′-(Trifluoromethyl)acetophenone a controlled substance?
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The provided data does not indicate that 2′-(Trifluoromethyl)acetophenone is a controlled substance.
How is 2′-(Trifluoromethyl)acetophenone packed and shipped?
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Tech Serve Solutions exports fine chemicals globally. Specific packing and shipping details for 2′-(Trifluoromethyl)acetophenone will be provided upon request, adhering to all relevant transportation regulations.
How can I request a quote or sample of 2′-(Trifluoromethyl)acetophenone?
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To request a quote or a sample of 2′-(Trifluoromethyl)acetophenone, please contact the Tech Serve Solutions sales team through our website or by phone.
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