2′,6′-Difluoroacetophenone
2′,6′-Difluoroacetophenone (CAS: 13670-99-0), with the molecular formula F₂C₆H₃COCH₃ and a molar mass of 156.13 g/mol, is a fluorinated organic building block. This compound serves as a key intermediate in organic synthesis, particularly in the preparation of more complex fluorinated molecules. Its specific structure makes it valuable for introducing the difluoroacetophenone moiety into diverse chemical structures across various research and development applications.
- Synonyms
- F2C6H3COCH3
Synthesis of Quinazoline Derivatives
2′,6′-Difluoroacetophenone has been utilised in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines. This application highlights its utility in constructing heterocyclic compounds with potential biological relevance.
Fluorinated Building Block in Organic Synthesis
As an aryl fluorinated building block, this compound is employed in diverse chemical synthesis pathways. Its difluorinated phenyl ring and acetophenone functionality allow for versatile reactions in the development of novel organic molecules.
Intermediate for Fine Chemicals
This chemical acts as an important intermediate in the production of specialised fine chemicals. It enables the incorporation of fluorine atoms, which can significantly alter the properties of target molecules, such as lipophilicity and metabolic stability.
| Molecular weight | 156.13 |
|---|---|
| Linear formula | F2C6H3COCH3 |
| Assay | 97% |
| Boiling point | 76-79 °C/15 mmHg(lit.) |
| Density | 1.197 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.48(lit.) |
| Application | 2′,6′-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 77 °C / 170.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2′,6′-Difluoroacetophenone used for?
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2′,6′-Difluoroacetophenone is primarily used as a building block in organic synthesis for the preparation of various chemical compounds, including quinazoline derivatives. It is valuable in research and development for creating novel fluorinated organic molecules.
What is the CAS number and formula for 2′,6′-Difluoroacetophenone?
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The CAS number for 2′,6′-Difluoroacetophenone is 13670-99-0. Its linear formula is F₂C₆H₃COCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2′,6′-Difluoroacetophenone with an assay of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2′,6′-Difluoroacetophenone be handled safely?
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According to the safety data, 2′,6′-Difluoroacetophenone is an irritant to the skin, eyes, and respiratory system (H315-H319-H335). Appropriate personal protective equipment, including eyeshields and gloves, should be worn. Ensure adequate ventilation or use a suitable respirator. Store in a well-ventilated place.
How is 2′,6′-Difluoroacetophenone exported and shipped?
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As a global supplier and exporter of fine chemicals, Tech Serve Solutions ships 2′,6′-Difluoroacetophenone adhering to all relevant international shipping regulations for chemical products. Contact us for specific export and shipping details.
How can I request a quote or sample for 2′,6′-Difluoroacetophenone?
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To request a quote or sample of 2′,6′-Difluoroacetophenone, please contact the Tech Serve Solutions sales team directly through our website or by phone. Provide your specific requirements for prompt service.
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