2-Phenylethanethiol
2-Phenylethanethiol (CAS 4410-99-5, C6H5CH2CH2SH) is a sulfur-containing organic compound with a molecular weight of 138.23 g/mol. This thiol plays a crucial role as a building block in chemical synthesis, particularly within materials science and micro/nanoelectronics. Its applications extend to the preparation of complex molecular clusters and as a derivatization reagent in analytical chemistry, enhancing mass spectrometry analysis.
- IUPAC
- 2-Phenylethyl mercaptan,Phenethyl mercaptan
- Synonyms
- 2-Phenylethyl mercaptanPhenethyl mercaptan
Preparation of Nanoclusters
2-Phenylethanethiol has been employed in the synthesis of gold nanoclusters, specifically biicosahedral Au(25) clusters, which are protected by various thiol ligands. This is important for creating precisely structured nanomaterials.
Mass Spectrometry Derivatization
It serves as a derivatization reagent for phosphorylated peptide sequences. This modification enhances ionization efficiency, leading to improved detection and analysis in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.
Organic Synthesis Building Block
As an organic building block, 2-Phenylethanethiol is utilized in constructing more complex organic molecules. Its reactive thiol group allows for versatile synthetic transformations.
Materials Science Applications
The compound finds applications in materials science, potentially in the development of self-assembly materials and surface modification due to the properties of the thiol group.
| Molecular weight | 138.23 |
|---|---|
| Linear formula | C6H5CH2CH2SH |
| Assay | 98% |
| Boiling point | 217-218 °C(lit.) |
| Density | 1.032 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.560(lit.) |
| Application | 2-Phenylethanethiol has been used:• in preparation of biicosahedral Au (25) clusters protected with various types of thiol ligands1• as derivatization reagent for phosphorylated sequences of peptides, for enhancing ionization efficiency in matrix-assisted laser desorption/ionization mass spectrometry2 |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | 90 °C / 194 °F |
| Transport (UN / ADR) | UN 3334 |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Phenylethanethiol used for?
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2-Phenylethanethiol is used in the preparation of gold nanoclusters, as a derivatization reagent for mass spectrometry of peptides, and as a versatile building block in organic synthesis and materials science.
What are the CAS number and chemical formula for 2-Phenylethanethiol?
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The CAS number is 4410-99-5 and the chemical formula is C6H5CH2CH2SH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Phenylethanethiol with an assay of 98%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
What are the primary safety hazards associated with 2-Phenylethanethiol?
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2-Phenylethanethiol is a combustible liquid (flash point 90 °C / 194 °F). Appropriate personal protective equipment, including eyeshields, gloves, and respiratory protection, should be used. It has a WGK rating of 3, indicating a high hazard to water.
How is 2-Phenylethanethiol packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant international regulations to ensure safe and secure delivery worldwide.
How can I request a sample or quote for 2-Phenylethanethiol?
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To request a sample or a quote for 2-Phenylethanethiol, please contact our sales team through the website or by phone.
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