2-Oxopropyltriphenylphosphonium chloride
2-Oxopropyltriphenylphosphonium chloride (CAS: 1235-21-8) is a valuable organophosphorus compound with the linear formula CH3COCH2P(Cl)(C6H5)3 and a molecular weight of 354.81 g/mol. It is a Wittig reagent commonly employed in organic synthesis for C-C bond formation. Its primary applications include the synthesis of unsaturated esters and ketones, and the preparation of fused heterocycles, making it a key intermediate in complex chemical syntheses.
- IUPAC
- Acetonyltriphenylphosphonium chloride
- Synonyms
- Acetonyltriphenylphosphonium chloride
Wittig Olefination Reagent
Utilised in Wittig reactions for the synthesis of olefins, it is particularly effective for creating unsaturated esters and ketones with multiple aromatic and heteroaromatic ring systems.
Synthesis of Heterocyclic Compounds
Serves as a reactant in regioselective cyclocondensation reactions, facilitating the formation of fused oxygen and nitrogen heterocyclic structures.
Investigation of Antimycobacterial Activities
Employed as a reactant in studies investigating the antimycobacterial properties of specific quinolone derivatives.
General Chemical Synthesis
A versatile reagent supporting broad applications in chemical synthesis, particularly for C-C bond formation and the creation of complex organic molecules.
| Molecular weight | 354.81 |
|---|---|
| Linear formula | CH3COCH2P(Cl)(C6H5)3 |
| Assay | 98% |
| Application | Used to investigate the antimycobacterial activities of Me alkenyl quinolones1Reactant for synthesis of: • Unsaturated esters and ketones containing multiple aromatic and heteroaromatic rings using Suzuki coupling - Wittig olefination2• Fused oxygen and nitrogen heterocycles via regioselective cyclocondensation3 Reactant for Wittig olefinations4 |
| Melting point | 243-245 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Oxopropyltriphenylphosphonium chloride used for?
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2-Oxopropyltriphenylphosphonium chloride is primarily used as a Wittig reagent for C-C bond formation, including the synthesis of unsaturated esters and ketones, and in the preparation of fused heterocyclic compounds. It has also been used to investigate the antimycobacterial activities of Me alkenyl quinolones.
What are the CAS number and chemical formula for 2-Oxopropyltriphenylphosphonium chloride?
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The CAS number is 1235-21-8 and the linear formula is CH3COCH2P(Cl)(C6H5)3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Oxopropyltriphenylphosphonium chloride with an assay of 98%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
How should 2-Oxopropyltriphenylphosphonium chloride be handled?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The substance has a WGK Germany classification of 3, indicating it is hazardous to water.
Is 2-Oxopropyltriphenylphosphonium chloride a controlled substance?
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The provided data does not indicate that 2-Oxopropyltriphenylphosphonium chloride is a controlled substance.
How is 2-Oxopropyltriphenylphosphonium chloride packed and shipped?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, adhering to all relevant shipping and export regulations.
How can I request a quote or sample for 2-Oxopropyltriphenylphosphonium chloride?
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Please contact our sales team or use the enquiry form on our website to request a quote or a sample of 2-Oxopropyltriphenylphosphonium chloride.
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