E-4031

CAS 113559-13-0C21H27N3O3S · 2HClCell Biology

E-4031 (CAS: 113559-13-0), a complex organic molecule with the formula C21H27N3O3S · 2HCl and a molecular weight of 474.44 g/mol, is supplied by TSS as an off-white solid. This compound is a research-grade chemical primarily utilised in scientific investigations concerning ion channels, cell signalling, and neuroscience. Its specific action on voltage-gated potassium channels makes it a valuable tool in electrophysiology and pharmacological research.

IUPAC: N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride

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E-4031 (C21H27N3O3S · 2HCl) — chemical structure, CAS 113559-13-0; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesCell BiologyIon ChannelsMonovalent Ion ChannelsPotassium Channel Modulators

01 /Applications

Ion Channel Research

E-4031 is extensively used as a specific blocker of voltage-gated potassium channels, particularly the h-ERG channel. Researchers utilise it to study the function and modulation of these critical ion channels in various physiological and pathological conditions.

Cell Signaling Studies

By modulating potassium channel activity, E-4031 can influence cellular electrical excitability and downstream signalling pathways. This makes it a useful probe for investigating cellular communication and responses in biological systems.

Neuroscience Investigations

Potassium channels play vital roles in neuronal function, including action potential generation and propagation. E-4031 helps neuroscientists explore these roles and understand the impact of potassium channel dysfunction in neurological disorders.

Pharmacological Tool

As a well-characterised chemical tool, E-4031 serves in pharmacological studies to assess the effects of potassium channel blockade. This aids in the development and testing of novel therapeutic agents targeting ion channelopathies.

02 /Properties

Molecular weight	474.44
Empirical formula	C21H27N3O3S · 2HCl
Assay	≥98% (HPLC)
Form	solid
Colour	off-white
Solubility	H2O: soluble
Storage temperature	−20°C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

113559-13-0

MDL number

MFCD01754739

05 /Additional specifications

Storage Condition	desiccated

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is E-4031 used for?

E-4031 is primarily used in scientific research as a specific blocker of voltage-gated potassium channels, particularly the h-ERG channel, aiding studies in cell biology, cell signalling, neuroscience, and ion channel modulation.

What is the CAS number and formula for E-4031?

The CAS number for E-4031 is 113559-13-0, and its empirical formula is C21H27N3O3S · 2HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies E-4031 with a purity of ≥98% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.

How should E-4031 be handled and stored?

E-4031 is supplied as an off-white solid. It should be handled with appropriate personal protective equipment, including eyeshields and gloves, and respiratory protection (type N95 or P1 filter). Store desiccated at -20°C to maintain its integrity.