2-Methoxyethyl chloroformate
2-Methoxyethyl chloroformate (CAS: 628-12-6) is a chemical compound with the linear formula CH3OCH2CH2OCOCl and a molecular weight of 138.55. As an acid halide and organic building block, it serves as a key reactant in various sophisticated organic synthesis pathways. Its applications include the preparation of potent enzyme inhibitors and novel heterocyclic compounds, contributing significantly to advancements in medicinal chemistry and materials science.
- IUPAC
- (2-Methoxyethoxy)carbonyl chloride,(Chloro)(2-methoxyethoxy)methanone,2-Methoxyethyl carbonochloridate,Chloroformic acid 2-methoxyethyl ester
Preparation of Enzyme Inhibitors
Used as a reactant in the synthesis of N-bridged bicyclic sulfonamides, which act as inhibitors of gamma-secretase, a critical target in neurodegenerative disease research.
Synthesis of Mitsunobu Reagents
Facilitates the preparation of dimethoxyethyl azodicarboxylate through amidation and oxidation, a reagent employed in the Mitsunobu reaction for stereoselective transformations.
Catalytic Cyanoesterification
Participates in nickel-catalyzed cyanoesterification reactions of allenes, enabling regioselective and stereoselective addition of chloroformates and TMSCN.
Development of Kinase Inhibitors
Employed in the synthesis of amino carboxamidobenzothiazoles, a class of compounds investigated for their potential as Lck (lymphocyte-specific protein tyrosine kinase) inhibitors.
Creation of Spirooxindole Structures
Acts as an acylating agent in stereoselective three-component coupling reactions to construct nonracemic spirooxindoles, allowing for further structural diversification.
| Molecular weight | 138.55 |
|---|---|
| Linear formula | CH3OCH2CH2OCOCl |
| Boiling point | 157-158 °C(lit.) |
| Density | 1.192 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4200(lit.) |
| Storage temperature | 2-8°C |
| Application | Reactant for:• Preparation of N-bridged bicyclic sulfonamides as inhibitors of γ-secretase1• Preparation of dimethoxyethyl azodicarboxylate via amidation/oxidation and application to Mitsunobu reaction2• Regioselective, stereoselective, and kinetically-controlled nickel-catalyzed cyanoesterification of allenes chloroformates and TMSCN3• Preparation of amino carboxamidobenzothiazoles as Lck inhibitors4• Preparation of nonracemic spirooxindoles using a stereoselective three-component coupling reaction as the key step and using acylation reactions to add structural diversity5 |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 58 °C / 136.4 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methoxyethyl chloroformate used for?
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2-Methoxyethyl chloroformate is primarily used as a reactant in organic synthesis for preparing complex molecules, including enzyme inhibitors, reagents for the Mitsunobu reaction, and novel heterocyclic compounds.
What are the CAS number and formula for 2-Methoxyethyl chloroformate?
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The CAS number for 2-Methoxyethyl chloroformate is 628-12-6, and its linear formula is CH3OCH2CH2OCOCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methoxyethyl chloroformate. The specific grade and purity are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.
How should 2-Methoxyethyl chloroformate be handled safely?
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2-Methoxyethyl chloroformate is a corrosive and flammable liquid (H314, H226). Handle with appropriate personal protective equipment, including gloves, eye protection (goggles and faceshield), and respiratory protection (type ABEK respirator filter), in a well-ventilated area. Refer to the Safety Data Sheet for comprehensive handling information.
Is 2-Methoxyethyl chloroformate supplied internationally?
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Yes, Tech Serve Solutions is a global supplier and exporter of chemicals, including 2-Methoxyethyl chloroformate, adhering to all relevant shipping regulations (UN 2920, 3(8), PGII).
How can I request a sample or quote for 2-Methoxyethyl chloroformate?
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To request a sample or a quote for 2-Methoxyethyl chloroformate, please contact our sales team via the website or by telephone, referencing the product name and CAS number.
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