2-Methoxyethyl acetoacetate
2-Methoxyethyl acetoacetate (CAS: 22502-03-0), with the molecular formula CH₃COCH₂CO₂CH₂CH₂OCH₃ and a molar mass of 160.17 g/mol, is a versatile organic building block. This ester serves as a valuable intermediate in chemical synthesis, particularly for creating more complex molecules. Its primary applications lie in the fine chemical and pharmaceutical industries, where it is employed in the development of novel compounds and active pharmaceutical ingredients.

Organic Synthesis Intermediate
Utilised as a key building block in multi-step organic syntheses, facilitating the construction of carbon skeletons and functional group transformations. Its reactive methylene group and ester functionality make it a versatile reagent.
Pharmaceutical Development
Serves as a precursor or intermediate in the synthesis of active pharmaceutical ingredients (APIs) and complex pharmaceutical compounds. Its structure allows for diverse derivatisation pathways.
Fine Chemical Manufacturing
Employed in the production of various fine chemicals, contributing to the development of specialty materials and research chemicals. It is a valuable component in custom synthesis projects.
| Molecular weight | 160.17 |
|---|---|
| Linear formula | CH3COCH2CO2CH2CH2OCH3 |
| Assay | ≥97.5% (GC) |
| Boiling point | 120 °C/20 mmHg(lit.) |
| Density | 1.09 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.434(lit.) |
| Impurities tested | ≤0.10% water≤1.5% 2-methoxyethanol |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 103 °C / 217.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methoxyethyl acetoacetate used for?
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2-Methoxyethyl acetoacetate is primarily used as an intermediate in organic synthesis and in the development of pharmaceuticals and fine chemicals. Its reactive nature makes it suitable for constructing more complex molecules.
What are the CAS number and molecular formula for 2-Methoxyethyl acetoacetate?
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The CAS number for 2-Methoxyethyl acetoacetate is 22502-03-0. Its linear molecular formula is CH₃COCH₂CO₂CH₂CH₂OCH₃.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methoxyethyl acetoacetate with an assay of ≥97.5% (GC). This is a technical/research grade, and TSS does not represent it as USP, BP, or EP grade.
What are the main safety hazards associated with 2-Methoxyethyl acetoacetate?
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2-Methoxyethyl acetoacetate is classified with the GHS symbol GHS07 and a Warning signal word. It carries hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Appropriate personal protective equipment, including eyeshields and gloves, should be used when handling.
How is 2-Methoxyethyl acetoacetate packed and shipped?
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2-Methoxyethyl acetoacetate is carefully packed according to industry standards to ensure safe transit and is exported globally by Tech Serve Solutions.
How can I request a quote or sample for 2-Methoxyethyl acetoacetate?
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To request a quote or sample of 2-Methoxyethyl acetoacetate, please contact the Tech Serve Solutions sales team through our website or direct inquiry channels.
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