2-Methoxy-4-nitrobenzenesulfonyl chloride
2-Methoxy-4-nitrobenzenesulfonyl chloride (CAS: 21320-91-2; Formula: CH3OC6H3(NO2)SO2Cl; MW: 251.64) is a specialized organic building block. It functions as a key intermediate in organic synthesis, particularly for introducing the 2-methoxy-4-nitrobenzenesulfonyl group into target molecules. This compound is primarily utilised in research and development settings for the creation of novel chemical entities and complex organic structures.

Organic Synthesis Intermediate
Serves as a versatile reagent for the synthesis of various organic compounds. Its sulfonyl chloride functionality allows for reactions with nucleophiles to form sulfonamides and sulfonates.
Building Block for Specialty Chemicals
Utilised in the preparation of more complex molecules for applications in materials science and fine chemical manufacturing. The presence of nitro and methoxy groups offers further modification possibilities.
Research and Development
Essential for laboratory-scale synthesis and exploration of new chemical pathways. Aids in the development of novel compounds with potential pharmaceutical or agrochemical applications.
| Molecular weight | 251.64 |
|---|---|
| Linear formula | CH3OC6H3(NO2)SO2Cl |
| Assay | 96% |
| Melting point | 90-95 °C(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methoxy-4-nitrobenzenesulfonyl chloride used for?
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2-Methoxy-4-nitrobenzenesulfonyl chloride (CAS: 21320-91-2) is primarily used as an intermediate in organic synthesis and as a building block for specialty chemicals in research and development.
What is the CAS number and chemical formula?
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The CAS number is 21320-91-2 and the linear chemical formula is CH3OC6H3(NO2)SO2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Methoxy-4-nitrobenzenesulfonyl chloride with an assay of 96%. This is a technical/research grade material, and TSS does not represent it as USP, BP, or EP grade.
What are the safety and handling precautions for this compound?
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This compound is classified as corrosive (GHS05, Danger, H314) and requires stringent safety measures. Handling should be done with appropriate personal protective equipment including eyeshields, face shields, chemical-resistant gloves, and respiratory protection, following PRECAUTIONARY STATEMENTS P280-P305 + P351 + P338-P310.
How is 2-Methoxy-4-nitrobenzenesulfonyl chloride shipped?
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According to ADR regulations, this compound is shipped as UN 3261, Class 8, Packing Group II, indicating it is a corrosive solid, acidic, organic, n.o.s.
How can I request a quote or sample?
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To request a quote or a sample of 2-Methoxy-4-nitrobenzenesulfonyl chloride, please contact the Tech Serve Solutions sales team through our website or by phone.
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