2-Methoxy-4-nitroaniline
2-Methoxy-4-nitroaniline (CAS: 97-52-9; Formula: CH3OC6H3(NO2)NH2; Molar Mass: 168.15 g/mol) is a chemical intermediate belonging to the aromatic amine and nitrogen compound families. It is primarily recognised for its application as a photometric reagent. This compound serves as a crucial building block in organic synthesis, particularly within the fine chemical and pharmaceutical sectors, enabling precise analytical determinations.
- IUPAC
- 4-Nitro-o-anisidine
- Synonyms
- 4-Nitro-o-anisidine

Photometric Reagent for Ethinylestradiol Determination
2-Methoxy-4-nitroaniline is employed as a specialised photometric reagent. Its specific reaction allows for the accurate determination of ethinylestradiol (ETE), a synthetic estrogen widely utilised in oral contraceptives.
Organic Synthesis Building Block
As a functionalised aromatic amine, this compound serves as a valuable building block in various organic synthesis pathways. It is integral to the creation of more complex molecules within the fine chemical industry.
Chemical Research and Development
This reagent finds application in research and development settings, contributing to advancements in analytical chemistry and the synthesis of novel compounds.
| Molecular weight | 168.15 |
|---|---|
| Linear formula | CH3OC6H3(NO2)NH2 |
| Assay | 98% |
| Application | 2-Methoxy-4-nitroaniline is used as a photometric reagent for the determination of ethinylestradiol (ETE), a semi-synthetic estrogen that is widely used in oral contraceptives1. |
| Melting point | 140-142 °C(lit.) |

Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Methoxy-4-nitroaniline used for?
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2-Methoxy-4-nitroaniline (CAS: 97-52-9) is primarily used as a photometric reagent for the determination of ethinylestradiol (ETE) and as a building block in organic synthesis.
What is the CAS number and chemical formula for 2-Methoxy-4-nitroaniline?
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The CAS number is 97-52-9, and the linear chemical formula is CH3OC6H3(NO2)NH2.
What grade and purity does Tech Serve Solutions supply for 2-Methoxy-4-nitroaniline?
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Tech Serve Solutions supplies 2-Methoxy-4-nitroaniline with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Methoxy-4-nitroaniline be handled safely?
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Handle 2-Methoxy-4-nitroaniline with appropriate personal protective equipment, including a dust mask (N95 type recommended), eyeshields, and gloves. It is classified as harmful if swallowed and causes skin and eye irritation, with potential respiratory irritation.
Is 2-Methoxy-4-nitroaniline available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Methoxy-4-nitroaniline, and can fulfil international orders.
How can I request a quote or sample for 2-Methoxy-4-nitroaniline?
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To request a quote or sample, please contact our sales team through the website or call us directly. Provide the product name (2-Methoxy-4-nitroaniline) and CAS number (97-52-9) for prompt service.
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