2-Mercaptopurine
2-Mercaptopurine (CAS 28128-19-0, C5H4N4S, MW: 152.18) is a thiopurine analog. It is primarily utilised in biochemical research to investigate enzyme kinetics, particularly xanthine oxidase-catalysed hydroxylation and myeloperoxidase (MPO) reactions. It has also been observed to inhibit lipopolysaccharide (LPS)-dependent nitric oxide (NO) production in B cells, making it a valuable tool for immunological studies.
- IUPAC
- 2-MP,2-Purinethiol,2-Thiopurine
- Synonyms
- 2-MP2-Purinethiol2-Thiopurine
Enzyme Kinetic Studies
2-Mercaptopurine serves as a substrate or inhibitor in research focused on the kinetics and binding specificities of enzymes such as xanthine oxidase and myeloperoxidase (MPO).
Immunological Research
This compound has demonstrated inhibitory effects on nitric oxide (NO) production in B cells stimulated by lipopolysaccharide (LPS), offering a tool for studying inflammatory pathways.
Biochemical Research Reagent
As a purine analog, 2-Mercaptopurine is employed in various biochemical investigations exploring cellular metabolic pathways and molecular interactions.
| Molecular weight | 152.18 |
|---|---|
| Empirical formula | C5H4N4S |
| Assay | ≥95% |
| Application | 2-Mercaptopurine (2-MP), a thiopurine and analog of the anti-cancer drug 6-mercaptopurine (6-MP), has been used to study the substrate and binding specificity and kinetics of xanthine oxidase-catalyzed hydroxylation and myeloperoxidase (MPO) reactions. 2-Mercaptopurine inhibited lipopolysacharide (LPS)-dependent nitric oxide (NO) production in B cells. |
Hazard statements
- H302Harmful if swallowed
- H318Causes serious eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Mercaptopurine used for?
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2-Mercaptopurine is used in biochemical research to study enzyme kinetics, specifically xanthine oxidase-catalysed hydroxylation and myeloperoxidase (MPO) reactions. It is also used to investigate the inhibition of lipopolysaccharide (LPS)-dependent nitric oxide (NO) production in B cells.
What is the CAS number and formula for 2-Mercaptopurine?
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The CAS number for 2-Mercaptopurine is 28128-19-0, and its empirical formula is C5H4N4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Mercaptopurine with an assay of ≥95%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Mercaptopurine be handled?
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2-Mercaptopurine is classified as Danger with hazards including H302 (Harmful if swallowed) and H318 (Causes serious eye damage). Handling requires appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, faceshields, and gloves. Always consult the Safety Data Sheet (SDS) for comprehensive handling procedures.
How is 2-Mercaptopurine packed, shipped, and exported?
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2-Mercaptopurine is carefully packed to ensure integrity during transit. Tech Serve Solutions is experienced in global export, adhering to all necessary regulations for shipping chemical compounds.
How can I request a sample or quote for 2-Mercaptopurine?
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To request a sample or a quote for 2-Mercaptopurine, please contact our sales team through the website or by phone, providing your specific requirements.
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