2-Hydroxyquinoline
2-Hydroxyquinoline (CAS 59-31-4), with the molecular formula C9H7NO and a molecular weight of 145.16 g/mol, is a valuable chemical intermediate. It is recognised for its utility in various chemical syntheses, particularly in the development of advanced materials and pharmaceutical agents. Its applications leverage its unique heterocyclic structure, making it a key building block for more complex molecules in research and industrial settings.
- IUPAC
- 2-Quinolinol,Carbostyril
- Synonyms
- 2-QuinolinolCarbostyril
Anticancer Drug Development
2-Hydroxyquinoline serves as a crucial precursor in the synthesis of platinum(IV) complexes. These complexes are designed as inert, stable prodrugs that can be photoactivated to release active platinum(II) species, demonstrating promising anticancer activity in preclinical studies.
Chemical Synthesis Intermediate
As a heterocyclic building block, 2-Hydroxyquinoline is employed in organic synthesis for constructing complex molecular architectures. Its reactivity profile makes it suitable for derivatisation in the creation of novel compounds for various research applications.
Photochemistry Research
The compound's structure facilitates the design of metal complexes with specific photophysical properties. Research involving 2-Hydroxyquinoline-derived platinum complexes has explored longer wavelength absorption bands for photoactivation purposes.
| Molecular weight | 145.16 |
|---|---|
| Empirical formula | C9H7NO |
| Assay | 98% |
| Solubility | alcohol: soluble(lit.)diethyl ether: soluble(lit.)dilute HCl: soluble(lit.)water: slightly soluble (1 g/950mL)(lit.) |
| Application | 2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity1. |
| Melting point | 198-199 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Hydroxyquinoline used for?
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2-Hydroxyquinoline is used as a building block in chemical synthesis, notably in the development of platinum(IV) complexes with potential anticancer activity. It is also employed in photochemistry research and for obtaining complex molecules with specific properties.
What is the CAS number and formula for 2-Hydroxyquinoline?
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The CAS number for 2-Hydroxyquinoline is 59-31-4, and its molecular formula is C9H7NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Hydroxyquinoline with an assay of 98%. This product is intended for laboratory and industrial use and is not represented as USP, BP, EP, or any other pharmacopoeial grade.
How should 2-Hydroxyquinoline be handled safely?
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2-Hydroxyquinoline is classified as dangerous. It is harmful if swallowed, causes skin irritation, serious eye damage, and may cause respiratory irritation. Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, must be worn. Handle only in a well-ventilated area.
Is 2-Hydroxyquinoline available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including 2-Hydroxyquinoline. We ensure compliance with international shipping regulations for chemical products.
How can I request a quote or sample for 2-Hydroxyquinoline?
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To request a quote or a sample of 2-Hydroxyquinoline, please contact our sales department through the website or by phone. Our team will be pleased to assist you with your specific requirements.
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