2-Hydroxyphenylboronic acid pinacol ester
2-Hydroxyphenylboronic acid pinacol ester (CAS 269409-97-4), with the molecular formula C12H17BO3 and a molecular weight of 220.07 g/mol, is a key organoboron compound. It is widely utilised as a building block in organic synthesis, particularly in palladium-catalyzed cross-coupling reactions like the Suzuki coupling. This reagent is supplied by Tech Serve Solutions for research and development purposes.
- IUPAC
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
- Synonyms
- 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
Suzuki Coupling Reactions
This boronate ester is a versatile reagent commonly employed in Suzuki-Miyaura cross-coupling reactions. It facilitates the formation of carbon-carbon bonds, making it invaluable in the synthesis of complex organic molecules, including pharmaceuticals and advanced materials.
Organic Synthesis Intermediate
As an aryl boronate ester, it serves as a crucial intermediate for introducing the 2-hydroxyphenyl moiety into various organic frameworks. Its predictable reactivity in coupling reactions makes it a reliable choice for synthetic chemists.
Pharmaceutical Research
The compound finds application in the research and development of new pharmaceutical agents. Its ability to participate in C-C bond formation is critical for constructing diverse molecular scaffolds with potential biological activity.
| Molecular weight | 220.07 |
|---|---|
| Empirical formula | C12H17BO3 |
| Assay | 98% |
| Boiling point | 282 °C(lit.) |
| Density | 1.05 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.506(lit.) |
| Application | Widely used in Suzuki coupling chemistry.6 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Hydroxyphenylboronic acid pinacol ester used for?
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2-Hydroxyphenylboronic acid pinacol ester is primarily used in organic synthesis, most notably as a key reagent in Suzuki coupling reactions for the formation of carbon-carbon bonds. It acts as a versatile building block in the synthesis of complex organic molecules, including those relevant to pharmaceutical research and materials science.
What are the CAS number and molecular formula?
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The CAS number for 2-Hydroxyphenylboronic acid pinacol ester is 269409-97-4, and its molecular formula is C12H17BO3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Hydroxyphenylboronic acid pinacol ester with an assay of 98%. This product is intended for laboratory and research use and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Hydroxyphenylboronic acid pinacol ester be handled safely?
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2-Hydroxyphenylboronic acid pinacol ester is classified with GHS07, a Warning signal word, and carries hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection in a well-ventilated area, and avoid ingestion, skin contact, and inhalation.
Can I request a sample or quote for this chemical?
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Yes, you can request a sample or a quote for 2-Hydroxyphenylboronic acid pinacol ester by contacting our sales team through the website or by calling us directly. Please specify the quantity required.
Is this chemical subject to any special regulations?
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Based on the provided data, there is no indication that 2-Hydroxyphenylboronic acid pinacol ester is a controlled substance. However, users should always verify compliance with local and international regulations.
How is this chemical exported and shipped?
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Tech Serve Solutions is a global supplier and exporter of fine chemicals. 2-Hydroxyphenylboronic acid pinacol ester is carefully packaged and shipped in compliance with all relevant international transportation regulations for chemical products.
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