2-Fluoro-5-methylphenylboronic acid

CAS 166328-16-1FC6H3(CH3)B(OH)2Chemical Synthesis

2-Fluoro-5-methylphenylboronic acid (CAS: 166328-16-1) is a versatile organoboron compound with the molecular formula FC6H3(CH3)B(OH)2 and a molecular weight of 153.95 g/mol. As an aryl boronic acid derivative, it serves as a crucial building block in organic synthesis, particularly in cross-coupling reactions. It is widely utilised in the development of novel pharmaceuticals, agrochemicals, and advanced materials due to its reactivity and functional group tolerance.

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2-Fluoro-5-methylphenylboronic acid (FC6H3(CH3)B(OH)2) — chemical structure, CAS 166328-16-1; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical Synthesis

01 /Applications

Suzuki-Miyaura Cross-Coupling Reactions

This boronic acid is an essential reagent for Suzuki-Miyaura coupling, enabling the formation of carbon-carbon bonds with aryl or vinyl halides. It is instrumental in synthesising complex organic molecules for pharmaceutical research and development.

Organic Synthesis Intermediate

Utilised as a key intermediate in multi-step syntheses, it facilitates the introduction of the 2-fluoro-5-methylphenyl moiety into target structures. This is valuable in the creation of functionalised aromatic compounds.

Materials Science

Its unique electronic and structural properties make it a component in the design and synthesis of novel organic materials, including those for electronic or optical applications.

02 /Properties

Molecular weight	153.95
Linear formula	FC6H3(CH3)B(OH)2
Assay	≥95%
Melting point	77-82 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

166328-16-1

MDL number

MFCD03428512

PubChem substance

24880365

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2-Fluoro-5-methylphenylboronic acid used for?

2-Fluoro-5-methylphenylboronic acid is primarily used as a building block in organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, and in the development of pharmaceuticals, agrochemicals, and advanced materials.

What is the CAS number and chemical formula?

The CAS number is 166328-16-1, and the chemical formula is FC6H3(CH3)B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2-Fluoro-5-methylphenylboronic acid with an assay of ≥95%. This product is intended for research and laboratory use and is not supplied as USP, BP, or EP grade.

How should 2-Fluoro-5-methylphenylboronic acid be handled?

Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Users should consult the Safety Data Sheet for detailed handling and hazard information. It is classified under WGK Germany 2.

Does TSS export 2-Fluoro-5-methylphenylboronic acid?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Fluoro-5-methylphenylboronic acid.

How can I request a quote or sample?

To request a quote or sample, please contact our sales team through the website or by phone. Please specify the product name and CAS number (166328-16-1) in your request.