2-Fluoro-3-pyridinecarboxaldehyde
2-Fluoro-3-pyridinecarboxaldehyde (CAS: 36404-90-7), with the molecular formula C6H4FNO and a molecular weight of 125.10 g/mol, is a fluorinated heterocyclic aldehyde. It serves as a valuable building block in organic synthesis. This compound is primarily utilised in the development of novel heterocyclic compounds, including the synthesis of naphthyridines through specific reaction pathways involving isoxazolinones and subsequent hydrogenolysis and cyclization.
- IUPAC
- 2-Fluoro-3-formylpyridine
- Synonyms
- 2-Fluoro-3-formylpyridine
Synthesis of Naphthyridines
This aldehyde is a key intermediate for the preparation of naphthyridine structures. It facilitates the attachment of isoxazolinones via fluoride displacement, followed by hydrogenolysis and cyclization reactions to yield the desired heterocyclic scaffolds.
Fluorinated Heterocyclic Chemistry
As a fluorinated pyridine derivative, it is employed in synthetic routes requiring the introduction of fluorine into heterocyclic systems, offering unique electronic and steric properties for downstream applications in medicinal chemistry and materials science.
Organic Building Block
Its reactive aldehyde group and the presence of fluorine on the pyridine ring make it a versatile building block for constructing more complex organic molecules and functionalized heterocycles.
| Molecular weight | 125.10 |
|---|---|
| Empirical formula | C6H4FNO |
| Assay | 97% |
| Boiling point | 50 °C/3 mmHg |
| Density | 1.250 g/mL at 25 °C |
| Refractive index | n20/D 1.520 |
| Application | Attachment of isoxazolinones by displacement of fluoride provide naphthyridines on hydrogenolysis and cyclization.1 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 73 °C / 163.4 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Fluoro-3-pyridinecarboxaldehyde used for?
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2-Fluoro-3-pyridinecarboxaldehyde (CAS: 36404-90-7) is used as a building block in organic synthesis, particularly for the preparation of naphthyridines and other fluorinated heterocyclic compounds.
What are the CAS number and molecular formula?
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The CAS number is 36404-90-7, and the molecular formula is C6H4FNO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Fluoro-3-pyridinecarboxaldehyde with an assay of 97%. TSS does not represent this product as USP, BP, or EP grade.
How should 2-Fluoro-3-pyridinecarboxaldehyde be handled safely?
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This compound is harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation (H302-H315-H319-H335). Appropriate personal protective equipment, including eyeshields, face shields, gloves, and a suitable respirator, should be used. Handle in a well-ventilated area.
Is 2-Fluoro-3-pyridinecarboxaldehyde a controlled substance?
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The provided data does not indicate that 2-Fluoro-3-pyridinecarboxaldehyde is a controlled substance.
How is this chemical packed, shipped, and exported?
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2-Fluoro-3-pyridinecarboxaldehyde is shipped as a non-hazardous material (NA 1993 / PGIII) where applicable, and Tech Serve Solutions handles global export with adherence to all necessary regulations.
How can I request a sample or quote for 2-Fluoro-3-pyridinecarboxaldehyde?
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Please contact the Tech Serve Solutions sales team via our website or direct inquiry channels to request a sample or a quotation for 2-Fluoro-3-pyridinecarboxaldehyde.
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