2-(Ethoxycarbonyl)phenylzinc bromide solution
2-(Ethoxycarbonyl)phenylzinc bromide solution (CAS: 131379-40-3) is an organozinc halide supplied by Tech Serve Solutions. With a molecular weight of 294.46 g/mol, this reagent is primarily utilised in organic synthesis. It is typically supplied as a 0.5 M solution in tetrahydrofuran (THF) and requires storage at 2-8°C due to its reactivity and potential to form explosive peroxides. Its applications are crucial in cross-coupling reactions and the formation of carbon-carbon bonds.
Organometallic Synthesis
This organozinc bromide serves as a valuable reagent in modern organic synthesis, enabling the introduction of aryl groups through various coupling reactions. Its controlled reactivity makes it suitable for complex molecular constructions.
Cross-Coupling Reactions
It is extensively used in palladium-catalyzed cross-coupling reactions, such as Negishi coupling, to form new carbon-carbon bonds. This is critical for building complex organic molecules in pharmaceutical and fine chemical industries.
Preparation of Pharmaceutical Intermediates
The compound is instrumental in the synthesis of advanced intermediates for active pharmaceutical ingredients (APIs). Its precise reactivity allows for selective functionalisation of complex molecular scaffolds.
| Molecular weight | 294.46 |
|---|---|
| Linear formula | C2H5O2CC6H4ZnBr |
| Density | 0.992 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Ethoxycarbonyl)phenylzinc bromide solution used for?
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2-(Ethoxycarbonyl)phenylzinc bromide solution is primarily used in organic synthesis, particularly in cross-coupling reactions like Negishi coupling, for the formation of carbon-carbon bonds and the synthesis of pharmaceutical intermediates.
What is the CAS number and formula for this product?
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The CAS number for 2-(Ethoxycarbonyl)phenylzinc bromide solution is 131379-40-3. Its linear formula is C2H5O2CC6H4ZnBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in THF. We do not represent this product as USP, BP, EP, or other pharmacopoeia grades. Please refer to the product's Certificate of Analysis for specific purity details.
How should 2-(Ethoxycarbonyl)phenylzinc bromide solution be handled and stored?
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This compound is flammable and can form explosive peroxides. It is an irritant to eyes and the respiratory system and is suspected of causing cancer. It must be stored at 2-8°C in a tightly sealed container under an inert atmosphere, away from ignition sources and oxidising agents.
How is this chemical packed and shipped?
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2-(Ethoxycarbonyl)phenylzinc bromide solution is packed in accordance with UN 2924 regulations for hazardous materials, shipped as a Class 8 corrosive liquid with a Class 3 subsidiary risk in Packing Group II. TSS exports globally, adhering to all relevant transport regulations.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales department via the website or directly by phone. Provide the product name, CAS number (131379-40-3), and your contact details.
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