2′-(Dicyclohexylphosphino)acetophenone ethylene ketal

CAS 221187-50-4C22H33O2PCatalysis & Inorganic

2′-(Dicyclohexylphosphino)acetophenone ethylene ketal (CAS 221187-50-4, C22H33O2P) is a phosphine ligand synthesised by Tech Serve Solutions. With a molecular weight of 360.47 g/mol, this compound serves as a crucial component in catalytic systems. It is particularly effective when used in conjunction with palladium catalysts for cross-coupling reactions, facilitating the synthesis of complex organic molecules.

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2′-(Dicyclohexylphosphino)acetophenone ethylene ketal (C22H33O2P) — chemical structure, CAS 221187-50-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical SynthesisPhosphine CompoundsPhosphine LigandsSymphos

01 /Applications

Palladium-Catalyzed Cross-Coupling

This phosphine ligand, when paired with Pd₂(dba)₃, forms an active catalyst for the cross-coupling of arylboronic acids with aryl chlorides. It demonstrates efficacy with both electron-rich and electron-poor aryl chloride substrates.

Ligand for Organometallic Catalysis

As a phosphine-based ligand, it can coordinate with transition metals like palladium, influencing the reactivity and selectivity of catalytic cycles. Its specific structure supports demanding coupling reactions in synthetic chemistry.

Chemical Synthesis Reagent

Utilised in the synthesis of complex organic compounds, this reagent plays a vital role in forming carbon-carbon bonds. Its application is particularly noted in the preparation of biaryl compounds.

02 /Properties

Molecular weight	360.47
Empirical formula	C22H33O2P
Assay	97%
Application	A P-O ligand that in combination with Pd2(dba)3 (cat. no. 328774) provides an active catalyst that effectively cross-couples a variety of arylboronic acids with aryl chlorides containing either electron-rich or electron-poor substituents.2
Melting point	85-92 °C

03 /Safety & handling

Hazard statements

H413May cause long-lasting harmful effects to aquatic life

Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

221187-50-4

MDL number

MFCD08705257

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2′-(Dicyclohexylphosphino)acetophenone ethylene ketal used for?

This compound is a phosphine ligand employed in palladium-catalysed cross-coupling reactions, particularly effective for coupling arylboronic acids with aryl chlorides. It is a key reagent in organic synthesis and catalysis.

What is the CAS number and formula for 2′-(Dicyclohexylphosphino)acetophenone ethylene ketal?

The CAS number is 221187-50-4, and the empirical formula is C22H33O2P.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product at an assay of 97%. This is typically considered a technical or research grade, and TSS does not represent it as USP, BP, EP, or other pharmacopoeia grades.

What are the safety considerations for handling 2′-(Dicyclohexylphosphino)acetophenone ethylene ketal?

According to GHS classifications, this compound carries the H413 hazard statement, indicating it may cause long-lasting harmful effects to aquatic life. Appropriate personal protective equipment should be used during handling.

Is 2′-(Dicyclohexylphosphino)acetophenone ethylene ketal available for export?

Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including this product. Please contact us for export details.