2-Cyanoethyl N,N-diisopropylchlorophosphoramidite
2-Cyanoethyl N,N-diisopropylchlorophosphoramidite (CAS: 89992-70-1) is a specialized organophosphorus compound with the linear formula [(CH3)2CH]2NP(Cl)OCH2CH2CN and a molecular weight of 236.68 g/mol. It serves as a crucial building block and coupling reagent in organic synthesis, particularly within chemical biology and nucleoside chemistry. This compound is essential for constructing complex molecules requiring specific phosphoramidite functionalities.
- IUPAC
- Chloro(diisopropylamino)-β-cyanoethoxyphosphine
- Synonyms
- [(CH3)2CH]2NP(Cl)OCH2CH2CNChloro(diisopropylamino)-β-cyanoethoxyphosphine
![2-Cyanoethyl N,N-diisopropylchlorophosphoramidite ([(CH3)2CH]2NP(Cl)OCH2CH2CN) — chemical structure, CAS 89992-70-1; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F89992-70-1.png&w=3840&q=75)
Nucleoside Synthesis
Utilised as a phosphitylating agent in the synthesis of modified nucleosides and oligonucleotides, enabling advancements in nucleic acid research and therapeutic development.
Organic Synthesis
Acts as a versatile building block for introducing phosphoramidite groups into various organic molecules. Its reactivity makes it valuable in multi-step synthetic pathways.
Chemical Biology
Employed in the creation of novel biochemical probes and modified biomolecules for studying biological processes and developing new diagnostic tools.
Coupling Reagent
Facilitates the efficient coupling of different molecular fragments, a key step in the construction of complex chemical structures.
| Molecular weight | 236.68 |
|---|---|
| Linear formula | [(CH3)2CH]2NP(Cl)OCH2CH2CN |
| Density | 1.061 g/mL at 25 °C(lit.) |
| Storage temperature | −20°C |
| Composition | Cl, 13.5-15.5% |
Hazard statements
- H250Catches fire spontaneously if exposed to air
- H314Causes severe skin burns and eye damage
Precautionary statements
- P222Do not allow contact with air
- P231Handle under inert gas
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
- P422
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 2845 4.2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 5-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite used for?
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This compound is primarily used as a building block and coupling reagent in organic synthesis, with significant applications in nucleoside chemistry and chemical biology for the synthesis of modified nucleosides and oligonucleotides.
What are the CAS number and formula for 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite?
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The CAS number is 89992-70-1, and its linear formula is [(CH3)2CH]2NP(Cl)OCH2CH2CN.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical as a research or technical grade material. We do not represent it as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How is 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite handled and stored?
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This compound is highly reactive and pyrophoric (H250), and causes severe skin burns and eye damage (H314). It must be handled under an inert atmosphere (P222, P231) with appropriate personal protective equipment, including gloves, goggles, and a face shield or respirator (P280). Store refrigerated at -20°C (P422) in a well-ventilated area.
How is this product packed, shipped, and exported?
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This product is carefully packed to maintain its stability and safety during transit, adhering to all relevant shipping regulations for hazardous materials. Tech Serve Solutions has extensive experience in exporting chemicals globally.
How can I request a sample or quote for this chemical?
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To request a sample or a quote, please contact our sales team through the provided channels on our website, specifying the product name and CAS number (89992-70-1).
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