2-Chloropyrimidine
2-Chloropyrimidine (CAS: 1722-12-9), with the chemical formula C4H3ClN2 and a molecular weight of 114.53 g/mol, is a halogenated heterocyclic compound. It serves as a valuable building block in organic synthesis, particularly for creating more complex pyrimidine derivatives. Its primary applications lie in chemical research and the development of novel compounds within the pharmaceutical and materials science sectors.
Synthesis of Novel Pyrimidine Derivatives
2-Chloropyrimidine is a key intermediate in the synthesis of various substituted pyrimidines. It has been employed in the preparation of novel bis(2-(pyrimidin-2-yl)ethoxy)alkanes and 2-amino-4-heteroarylpyrimidines, showcasing its utility in heterocyclic chemistry.
Fluorescent Dye and Biosensor Development
This compound has been utilised in the construction of complex fluorescent dyes. For instance, it was incorporated into the synthesis of a fluorescent dye used as a biosensor for protein assays, highlighting its role in advanced analytical chemistry applications.
Preparation of Pyrrolopyridine Derivatives
2-Chloropyrimidine has been instrumental in the synthesis of cis- and trans-octahydropyrrolo[2,3]pyridine derivatives. This demonstrates its versatility as a precursor for fused heterocyclic systems with potential pharmaceutical relevance.
| Molecular weight | 114.53 |
|---|---|
| Empirical formula | C4H3ClN2 |
| Assay | 95% |
| Boiling point | 75-76 °C/10 mmHg(lit.) |
| Application | 2-Chloropyrimidine was used in the synthesis of:• novel bis(2-(pyrimidin-2-yl)ethoxy)alkanes1• 4′-(1,1′-(5-(2-methoxyphenoxy)-[2,2′-bipyrimidine]-4,6-diyl)bis(1H-pyrazol-3,1-diyl)) dianiline fluorescent dye, biosensor for protein assay2• cis- and trans-octahydropyrrolo[2,3]pyridine derivatives3• 2-amino-4-heteroarylpyrimidines4 |
| Melting point | 63-66 °C(lit.) |
Hazard statements
- H301Toxic if swallowed
- H319Causes serious eye irritation
Precautionary statements
- P301IF SWALLOWED
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Flash point | 98 °C / 208.4 °F |
| Transport (UN / ADR) | UN 2811 6.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloropyrimidine used for?
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2-Chloropyrimidine is used as a building block in organic synthesis, particularly for the preparation of novel pyrimidine derivatives, fluorescent dyes, and heterocyclic compounds like octahydropyrrolo[2,3]pyridines.
What is the CAS number and chemical formula for 2-Chloropyrimidine?
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The CAS number for 2-Chloropyrimidine is 1722-12-9, and its chemical formula is C4H3ClN2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloropyrimidine with an assay of 95%. We do not represent this product as USP, BP, or EP grade; it is suitable for research and technical applications.
How should 2-Chloropyrimidine be handled safely?
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2-Chloropyrimidine is classified as Danger (GHS06). It is toxic if swallowed (H301) and causes serious eye irritation (H319). Handle with appropriate personal protective equipment including a dust mask (type N95 US), eyeshields, face shields, and gloves. Avoid dust formation and ensure good ventilation. It is classified under WGK Germany 3.
How is 2-Chloropyrimidine shipped and exported?
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2-Chloropyrimidine is shipped and exported according to international regulations, identified as UN 2811, Class 6.1, Packing Group III. Tech Serve Solutions is an experienced global supplier and exporter.
How can I request a quote or sample for 2-Chloropyrimidine?
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To request a quote or a sample of 2-Chloropyrimidine, please use the 'Request Quote' or 'Request Sample' buttons on our product page or contact our sales team directly.
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