2-(Chloromethyl)pyridine hydrochloride
2-(Chloromethyl)pyridine hydrochloride (CAS: 6959-47-3; Formula: C6H6ClN · HCl; MW: 164.03) is a valuable pyridine derivative supplied by Tech Serve Solutions. This chemical serves as a key building block in complex organic synthesis, particularly within heterocyclic chemistry. Its primary utility lies in its role as a reagent for alkylation reactions, facilitating the introduction of the 2-picolyl group in the synthesis of advanced pharmaceutical intermediates and research chemicals.
- IUPAC
- 2-Picolyl chloride hydrochloride
- Synonyms
- 2-Picolyl chloride hydrochloride
Reagent in Alkylation Reactions
Utilized as a reagent in base-catalyzed alkylation of calixarenes, such as p-tert-butylcalix[6]arene and p-tert-butylcalix[5]arene, often in polar aprotic solvents like DMF.
Synthesis of MRI Contrast Agents
Employed in the synthesis of specific complexes, such as a Gd3+ diethylenetriaminepentaacetic acid bisamide complex, which functions as a Zn2+-sensitive magnetic resonance imaging contrast agent.
Heterocyclic Building Block
Serves as a versatile intermediate in the construction of more complex heterocyclic pyridine-containing molecules for various chemical research and development applications.
| Molecular weight | 164.03 |
|---|---|
| Empirical formula | C6H6ClN · HCl |
| Assay | ≥98.0% (AT) |
| Application | 2-(Chloromethyl)pyridine hydrochloride was used as reagent in base catalyzed alkylation of p-tert-butylcalix[6]arene1 and p-tert-butylcalix[5]arene2 in DMF. It was used in the synthesis of Gd3+ diethylenetriaminepentaacetic acid bisamide complex, a Zn2+-sensitive magnetic resonance imaging contrast agent3. |
| Melting point | 120-124 °C(lit.)120-124 °C |
Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Chloromethyl)pyridine hydrochloride used for?
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2-(Chloromethyl)pyridine hydrochloride is primarily used as a reagent in base-catalyzed alkylation reactions and as a building block in chemical synthesis, including the preparation of MRI contrast agents.
What is the CAS number and formula for 2-(Chloromethyl)pyridine hydrochloride?
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The CAS number is 6959-47-3, and the empirical formula (Hill notation) is C6H6ClN · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-(Chloromethyl)pyridine hydrochloride with an assay of ≥98.0% (AT). This is a technical/research grade; TSS does not represent it as USP, BP, or EP grade.
How should 2-(Chloromethyl)pyridine hydrochloride be handled safely?
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2-(Chloromethyl)pyridine hydrochloride is a Danger material, causing severe skin burns and eye damage (H314) and is harmful if swallowed (H302). Appropriate personal protective equipment, including eyeshields, faceshields, gloves, and respiratory protection, must be used. In case of contact, immediate medical attention is required.
How is 2-(Chloromethyl)pyridine hydrochloride packed and shipped?
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This chemical is classified as UN 3261, Hazard Class 8, Packing Group III. It is exported by TSS in compliance with all relevant transport regulations.
How can I request a sample or quote for 2-(Chloromethyl)pyridine hydrochloride?
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To request a sample or a quotation for 2-(Chloromethyl)pyridine hydrochloride, please contact our sales department via the website or email.
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