2-Chloro-6-methoxyphenylboronic acid
2-Chloro-6-methoxyphenylboronic acid (CAS: 385370-80-9) is an organoboron compound with the formula ClC6H3(OCH3)B(OH)2 and a molecular weight of 186.40 g/mol. This aryl boronic acid serves as a valuable building block in organic synthesis. It is primarily utilised as a reactant in Suzuki coupling reactions and for the preparation of various complex organic molecules, including potential pharmaceutical intermediates.
- IUPAC
- 2-Chloro-6-methoxybenzeneboronic acid,6-Chloro-2-methoxyphenylboronic acid
Suzuki Coupling Reactions
This compound is an effective reactant in Suzuki and Suzuki-Miyaura coupling reactions, which are fundamental C-C bond-forming processes catalysed by palladium. It facilitates the introduction of the 2-chloro-6-methoxyphenyl moiety into various organic frameworks.
Cholesteryl Ester Transfer Protein Inhibitors
It has been employed in the synthesis of potential inhibitors for cholesteryl ester transfer protein. Research in this area aims to explore methods for increasing high-density lipoprotein cholesterol (HDLc) levels.
Indole Synthesis
2-Chloro-6-methoxyphenylboronic acid is used in the solid-phase synthesis of 2,3,5-trisubstituted indoles, a class of heterocyclic compounds with significant pharmaceutical relevance.
| Molecular weight | 186.40 |
|---|---|
| Linear formula | ClC6H3(OCH3)B(OH)2 |
| Assay | ≥95% |
| Application | Reactant for:• Suzuki coupling1,2• Preparation of inhibitors of cholesteryl ester transfer protein to raise HDLc levels3• Pd-catalyzed Suzuki-Miyaura coupling4• Solid-phase synthesis of 2,3,5-trisubstituted indoles5 |
| Melting point | 162-165 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-6-methoxyphenylboronic acid used for?
+
2-Chloro-6-methoxyphenylboronic acid is used as a reactant in Suzuki coupling reactions, for the preparation of inhibitors of cholesteryl ester transfer protein, and in the solid-phase synthesis of indoles.
What is the CAS number and chemical formula for 2-Chloro-6-methoxyphenylboronic acid?
+
The CAS number is 385370-80-9 and the chemical formula is ClC6H3(OCH3)B(OH)2.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 2-Chloro-6-methoxyphenylboronic acid with a minimum purity of 95% (assay). This product is supplied for research and development or further manufacturing purposes. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
What are the safety considerations when handling 2-Chloro-6-methoxyphenylboronic acid?
+
When handling 2-Chloro-6-methoxyphenylboronic acid, appropriate personal protective equipment, including eyeshields and gloves, must be worn. A respirator filter suitable for type N95 (US) or type P1 (EN143) should be used. The substance has a WGK Germany rating of 3.
Is 2-Chloro-6-methoxyphenylboronic acid a controlled substance?
+
Based on the provided data, there is no indication that 2-Chloro-6-methoxyphenylboronic acid is a controlled substance.
How is 2-Chloro-6-methoxyphenylboronic acid packed and shipped?
+
Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific packaging and shipping details can be provided upon request, adhering to all relevant international regulations for chemical transport.
How can I request a sample or quote for 2-Chloro-6-methoxyphenylboronic acid?
+
To request a sample or a quotation, please contact the Tech Serve Solutions sales team through our official website or by direct inquiry. Please reference the product name and CAS number (385370-80-9).
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis