2-Chloro-4-methoxypyrimidine
2-Chloro-4-methoxypyrimidine (CAS: 22536-63-6) is a halogenated heterocyclic organic compound with the molecular formula C5H5ClN2O and a molecular weight of 144.56 g/mol. This white to off-white solid serves as a valuable building block in chemical synthesis. Its structure, featuring both a pyrimidine ring and a chlorine atom, allows for diverse chemical transformations, making it a key intermediate in the development of various complex organic molecules, particularly within pharmaceutical research and fine chemical manufacturing.

Pharmaceutical Intermediate
2-Chloro-4-methoxypyrimidine is utilised as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its reactive sites enable the construction of more complex molecular scaffolds relevant to drug discovery and development.
Organic Synthesis Reagent
As a versatile building block, it is employed in a wide range of organic synthesis reactions. The presence of the chlorine atom and the pyrimidine core allows for nucleophilic substitution and other derivatisation reactions.
Research and Development
This compound is frequently used in academic and industrial research laboratories for exploring new synthetic pathways and creating novel chemical entities with potential applications in materials science or agrochemicals.
| Molecular weight | 144.56 |
|---|---|
| Empirical formula | C5H5ClN2O |
| Assay | 98% |
| Melting point | 54-57 °C(lit.) |

Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-4-methoxypyrimidine used for?
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2-Chloro-4-methoxypyrimidine (CAS: 22536-63-6) is primarily used as a building block in organic synthesis, serving as an intermediate in the development of pharmaceuticals and other complex organic molecules. It is also utilised in research and development laboratories.
What are the CAS number and formula for 2-Chloro-4-methoxypyrimidine?
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The CAS number for 2-Chloro-4-methoxypyrimidine is 22536-63-6, and its empirical formula is C5H5ClN2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Chloro-4-methoxypyrimidine with an assay of 98%. We do not represent this product as USP, BP, EP, or for pharmaceutical, nutraceutical, or food use.
How should 2-Chloro-4-methoxypyrimidine be handled safely?
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Handle 2-Chloro-4-methoxypyrimidine with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. It is a warning substance that may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335).
Does TSS export 2-Chloro-4-methoxypyrimidine?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Chloro-4-methoxypyrimidine.
How can I request a quote or sample for 2-Chloro-4-methoxypyrimidine?
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To request a quote or sample for 2-Chloro-4-methoxypyrimidine, please contact our sales team via the website or by phone.
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