2-Chloro-4′-fluoroacetophenone
2-Chloro-4′-fluoroacetophenone (CAS 456-04-2) is a fluorinated aryl ketone with the molecular formula C8H6ClO F and a molecular weight of 172.58 g/mol. This compound serves as a valuable building block in organic synthesis, particularly in the creation of complex pharmaceutical intermediates and bioactive molecules. Its structure facilitates various chemical transformations, making it a key reagent for researchers and industrial chemists.
- IUPAC
- ω-Chloro-4-fluoroacetophenone,4-Fluorophenacyl chloride
- Synonyms
- 4-Fluorophenacyl chlorideω-Chloro-4-fluoroacetophenone1-(4-Fluorophenyl)-2-chloroethanone
Synthesis of Pharmaceutical Intermediates
2-Chloro-4′-fluoroacetophenone is employed as a starting material or intermediate in the multi-step synthesis of advanced pharmaceutical compounds. Its reactive chloroacetyl group and fluorinated phenyl ring allow for diverse functionalization pathways.
Preparation of Bioactive Molecules
This chemical is utilised in research and development for the creation of novel bioactive small molecules. Documented applications include its use in the synthesis of specific glutathione conjugates and complex azabicyclo compounds.
Organic Synthesis Building Block
As a versatile fluorinated building block, it facilitates the introduction of the 4-fluorophenacyl moiety into target molecules. It is instrumental in C-C bond formation and other key organic transformations.
| Molecular weight | 172.58 |
|---|---|
| Linear formula | FC6H4COCH2Cl |
| Assay | 99% |
| Application | 2-Chloro-4′-fluoroacetophenone was used in the synthesis of S-(phenacyl)glutathiones1 and 2-[3-(4-chlorophenyl)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-(4-fluorophenyl)ethanone2. |
| Melting point | 47-50 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 110 °C / 230 °F |
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-28 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Gene Information | human ... PTPN6(5777) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Chloro-4′-fluoroacetophenone primarily used for?
+
2-Chloro-4′-fluoroacetophenone is primarily used as a building block in organic synthesis, particularly for the preparation of pharmaceutical intermediates and other bioactive molecules.
What is the CAS number and formula for 2-Chloro-4′-fluoroacetophenone?
+
The CAS number is 456-04-2, and its linear formula is C8H6ClO F.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 2-Chloro-4′-fluoroacetophenone with a minimum assay of 99%. We do not represent this product as USP, BP, or EP grade.
How should 2-Chloro-4′-fluoroacetophenone be handled safely?
+
Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (type N95 US). It is classified as a Warning with hazards H315 (causes skin irritation), H319 (causes serious eye irritation), and H335 (may cause respiratory irritation).
Is 2-Chloro-4′-fluoroacetophenone suitable for export?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 2-Chloro-4′-fluoroacetophenone, which is shipped under UN 3261, Hazard Class 8, Packing Group II.
How can I request a quote or sample?
+
To request a quote or sample of 2-Chloro-4′-fluoroacetophenone, please contact our sales team through the website or by phone.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis