2-Chloro-2′-deoxyadenosine

CAS 4291-63-8C10H12ClN5O3Biochemicals & Reagents

2-Chloro-2′-deoxyadenosine (CAS 4291-63-8), with the molecular formula C10H12ClN5O3, is a chlorinated purine nucleoside analogue. It exhibits activity against certain lymphoproliferative disorders by resisting ADA degradation and undergoing intracellular phosphorylation to CdATP. This active metabolite induces DNA strand breaks and apoptosis in lymphocytes. 2-CdA is also recognised for its potential role in studies investigating DNA polymerase inhibition.

IUPAC: CdA,Cladribine
Synonyms: CdACladribine

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2-Chloro-2′-deoxyadenosine (C10H12ClN5O3) — chemical structure, CAS 4291-63-8; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsC-CHCell BiologyNucleoside AnalogsNucleosidesNucleotidesOligonucleotides More...

01 /Applications

Treatment of Lymphoproliferative Disorders

2-Chloro-2′-deoxyadenosine demonstrates efficacy in managing conditions such as hairy cell leukemia (HCL) and multiple myeloma (MM). Its mechanism involves intracellular conversion to CdATP, which disrupts DNA synthesis and promotes programmed cell death in malignant lymphocytes.

Research in DNA Polymerase Inhibition

This compound serves as a valuable tool in biochemical research for investigating the mechanisms of DNA polymerases. Its ability to interfere with DNA replication pathways makes it a subject of study in understanding cellular processes and potential therapeutic targets.

Apoptosis Studies

2-CdA is employed in cell biology research to induce and study apoptosis. By causing DNA strand breaks via CdATP, it provides a reliable method for researchers to explore the complex pathways of programmed cell death.

02 /Properties

Molecular weight	285.69
Empirical formula	C10H12ClN5O3
Storage temperature	2-8°C
Application	2-Chloro-2′-deoxyadenosine (2-CdA) is a chlorinated purine nucleoside with activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL) and multiple myeloma (MM). 2-CdA resists ADA degradation and is phosphorylated to CdATP in lymphocytes. CdATP incorporation into DNA induces strand breaks and the activation of apoptosis. 2-CdA may also be used in studies involving the inhibition of DNA polymerase(s).Cladribiane, like fludarabine, is a prodrug that is must be phosphorylated intracellularly to the monophosphate by the nuclear/cytosol enzyme deoxycytidine kinase (dCK) and possibly by the mitochondrial enzyme deoxyguanosine kinase (dGK).

03 /Safety & handling

GHS hazard pictogram: Toxic (GHS06) — Toxic

Danger

Hazard statements

H301Toxic if swallowed
H311Toxic in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P280Wear protective gloves, clothing and eye/face protection
P301IF SWALLOWED
P305IF IN EYES
P311Call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Water hazard class (WGK, DE)	3
Hazard codes (EU)	T
Risk statements (R)	23/24/25-36/37/38
Safety statements (S)	22-26-36-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

4291-63-8

MDL number

MFCD00153939

PubChem substance

24892693

05 /Additional specifications

Gene Information	human ... NP(4860)rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is 2-Chloro-2′-deoxyadenosine used for?

2-Chloro-2′-deoxyadenosine (2-CdA) is used in research for its activity against lymphoproliferative disorders like hairy cell leukemia and multiple myeloma, and for studies involving the inhibition of DNA polymerases and induction of apoptosis.

What are the CAS number and formula for 2-Chloro-2′-deoxyadenosine?

The CAS number for 2-Chloro-2′-deoxyadenosine is 4291-63-8, and its empirical formula is C10H12ClN5O3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2-Chloro-2′-deoxyadenosine primarily as a research-grade chemical. We do not represent this product as meeting USP, BP, EP, or any other pharmacopoeia standards. Please refer to the product's Certificate of Analysis for specific purity details.

How should 2-Chloro-2′-deoxyadenosine be handled?

Handle 2-Chloro-2′-deoxyadenosine with appropriate personal protective equipment, including eyeshields, face shields, gloves, and a P2 respirator cartridge if dust or aerosols are generated. It is labelled with danger signals (GHS06) and carries significant hazard statements (H301-H311-H315-H319-H331-H335).

How is 2-Chloro-2′-deoxyadenosine shipped?

2-Chloro-2′-deoxyadenosine is typically shipped under refrigeration (2-8°C). As a specialist global supplier, Tech Serve Solutions adheres to all relevant regulations for the export of fine chemicals.

How can I request a sample or quote for 2-Chloro-2′-deoxyadenosine?

To request a sample or obtain a quote for 2-Chloro-2′-deoxyadenosine, please contact our sales department via our website or by telephone, providing your specific requirements and shipping details.