2-Bromopyridine-3-boronic acid pinacol ester
2-Bromopyridine-3-boronic acid pinacol ester (CAS: 452972-12-2) is a valuable organoboron compound with the molecular formula C11H15BBrNO2 and a molecular weight of 283.96 g/mol. This heteroaryl boronate ester is widely employed in organic synthesis, particularly in cross-coupling reactions. Its unique structure makes it a key building block for constructing complex molecules in pharmaceutical research and materials science.
- IUPAC
- 2-Bromo-3-pyridineboronic acid pinacol ester
- Synonyms
- 2-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Suzuki-Miyaura Cross-Coupling Reactions
This pinacol ester serves as an excellent coupling partner in palladium-catalysed Suzuki-Miyaura reactions, enabling the formation of new carbon-carbon bonds. It is particularly useful for introducing substituted pyridine moieties into organic structures.
Pharmaceutical Intermediate Synthesis
The compound is a crucial intermediate in the synthesis of various pharmaceutical agents. Its pyridine core and boronic ester functionality allow for regioselective functionalization in the development of novel drug candidates.
Materials Science
It finds application in the development of advanced materials, such as organic light-emitting diodes (OLEDs) and other functional organic materials, where specific electronic and photophysical properties are desired.
Agrochemical Research
2-Bromopyridine-3-boronic acid pinacol ester can be utilised in the research and development of new agrochemicals, contributing to the synthesis of compounds with potential pesticidal or herbicidal activity.
| Molecular weight | 283.96 |
|---|---|
| Empirical formula | C11H15BBrNO2 |
| Assay | 90% |
| Density | 1.329 g/mL at 25 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromopyridine-3-boronic acid pinacol ester used for?
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2-Bromopyridine-3-boronic acid pinacol ester is primarily used as a coupling partner in palladium-catalysed cross-coupling reactions, such as the Suzuki-Miyaura reaction, for the synthesis of complex organic molecules, particularly in pharmaceutical research, materials science, and agrochemical development.
What are the CAS number and molecular formula?
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The CAS number for 2-Bromopyridine-3-boronic acid pinacol ester is 452972-12-2. Its molecular formula is C11H15BBrNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromopyridine-3-boronic acid pinacol ester with an assay of 90%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-Bromopyridine-3-boronic acid pinacol ester be handled?
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Based on its hazard statements (H315, H319, H335), this compound is classified as a Warning. It causes skin irritation, serious eye irritation, and may cause respiratory irritation. Appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator, should be used. Handle in a well-ventilated area.
Is this chemical a controlled substance?
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The provided data does not indicate that 2-Bromopyridine-3-boronic acid pinacol ester is a controlled substance.
How is this product packaged and exported by TSS?
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Tech Serve Solutions, as a specialist global supplier and exporter, ensures appropriate packaging for safe transport and export of chemicals worldwide.
How can I request a quote or sample?
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Please contact our sales team via the website or direct inquiry channels to request a quote or a sample of 2-Bromopyridine-3-boronic acid pinacol ester.
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