2-Bromo-5-fluorotoluene
2-Bromo-5-fluorotoluene (CAS: 452-63-1) is a fluorinated aromatic compound with the chemical formula CH3C6H3(Br)F. It has a molecular weight of 189.02 g/mol. This versatile building block is primarily utilised in organic synthesis for the creation of more complex molecules. Its specific structure, featuring both bromine and fluorine substituents on a toluene backbone, makes it a valuable intermediate in the pharmaceutical and agrochemical industries.
Pharmaceutical Intermediate
2-Bromo-5-fluorotoluene serves as a key building block in the synthesis of various pharmaceutical compounds. Its reactive sites allow for functional group transformations essential for developing novel drug candidates.
Agrochemical Synthesis
This compound is employed in the development of new agrochemicals, contributing to the synthesis of active ingredients for pesticides and herbicides. The presence of fluorine can enhance biological activity and stability.
Organic Synthesis Reagent
As a halogenated aromatic, 2-Bromo-5-fluorotoluene is a useful reagent in general organic synthesis, enabling cross-coupling reactions and the introduction of fluorinated aryl moieties into target molecules.
| Molecular weight | 189.02 |
|---|---|
| Linear formula | CH3C6H3(Br)F |
| Assay | 98% |
| Boiling point | 177 °C/756 mmHg(lit.) |
| Density | 1.495 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.526(lit.) |
Hazard statements
- H226Flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 45 °C / 113 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 10-36/37/38 |
| Safety statements (S) | 16-26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-5-fluorotoluene used for?
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2-Bromo-5-fluorotoluene is used as an intermediate in organic synthesis, particularly for the preparation of pharmaceuticals and agrochemicals. It serves as a building block for introducing fluorinated aryl groups.
What is the CAS number and formula for 2-Bromo-5-fluorotoluene?
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The CAS number is 452-63-1, and the chemical formula is CH3C6H3(Br)F.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-Bromo-5-fluorotoluene with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 2-Bromo-5-fluorotoluene?
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2-Bromo-5-fluorotoluene is a flammable liquid and vapour (H226), causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields, gloves, and suitable respiratory protection, must be used. Handle in a well-ventilated area away from ignition sources.
How is 2-Bromo-5-fluorotoluene packed, shipped, and exported?
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2-Bromo-5-fluorotoluene is packed in accordance with international regulations for hazardous materials. Tech Serve Solutions exports globally, ensuring compliance with all relevant shipping and customs requirements.
How can I request a quote or sample for 2-Bromo-5-fluorotoluene?
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To request a quote or a sample of 2-Bromo-5-fluorotoluene, please contact our sales department through the website or by phone.
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