2-Bromo-1,4-difluorobenzene
2-Bromo-1,4-difluorobenzene (CAS 399-94-0) is a halogenated aromatic compound with the linear formula BrC6H3F2. Possessing a molecular weight of 192.99 g/mol, this chemical serves as a valuable building block in organic synthesis. It is primarily utilised in the preparation of more complex molecules, including intermediates for pharmaceutical research and material science applications. Tech Serve Solutions offers this compound with a typical assay of 98%.
- Synonyms
- BrC6H3F2
Synthesis of Anthraquinone Derivatives
2-Bromo-1,4-difluorobenzene has been employed in the synthesis of 1,4-difluoroanthraquinone. This anthraquinone derivative is a key precursor for the production of ametantrone, a pharmaceutical agent.
Fluorinated Building Block
As a difluorinated aryl bromide, this compound is an important synthon for introducing the 1,4-difluorobenzene moiety into larger organic structures. Its utility spans various research and development projects in medicinal chemistry and materials science.
Organic Synthesis Intermediate
The presence of both bromine and fluorine atoms on the benzene ring allows for diverse chemical transformations. It can participate in cross-coupling reactions and nucleophilic aromatic substitution, facilitating the construction of complex organic molecules.
| Molecular weight | 192.99 |
|---|---|
| Linear formula | BrC6H3F2 |
| Assay | 98% |
| Boiling point | 58-59 °C/20 mmHg(lit.) |
| Density | 1.708 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.508(lit.) |
| Application | 2-Bromo-1,4-difluorobenzene has been used in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone1. |
| Melting point | −31 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 65 °C / 149 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-Bromo-1,4-difluorobenzene used for?
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2-Bromo-1,4-difluorobenzene is primarily used as a building block in organic synthesis, notably in the preparation of 1,4-difluoroanthraquinone, a precursor to ametantrone.
What is the CAS number and formula for 2-Bromo-1,4-difluorobenzene?
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The CAS number is 399-94-0 and the linear formula is BrC6H3F2.
What grade and purity does Tech Serve Solutions supply for 2-Bromo-1,4-difluorobenzene?
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Tech Serve Solutions supplies 2-Bromo-1,4-difluorobenzene with a purity of 98%. We do not represent this product as meeting USP/BP/EP pharmacopoeial standards.
How should 2-Bromo-1,4-difluorobenzene be handled safely?
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2-Bromo-1,4-difluorobenzene is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be worn. Ensure adequate ventilation and use a suitable respirator cartridge.
How is 2-Bromo-1,4-difluorobenzene packed and shipped?
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This chemical is shipped under NA 1993, Packing Group III. Specific packaging details are available upon request, and TSS is experienced in exporting fine chemicals globally.
How can I request a quote or sample for 2-Bromo-1,4-difluorobenzene?
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Please contact our sales team via the website or direct email to request a quotation or a sample of 2-Bromo-1,4-difluorobenzene.
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