Phenyl isothiocyanate
Phenyl isothiocyanate (CAS 103-72-0, C6H5NCS) is a key organic building block with a molecular weight of 135.19 g/mol. This sulfur compound is primarily utilised as a derivatising reagent in analytical chemistry. Its reactivity makes it indispensable for the sequencing of peptides via Edman degradation and for amino acid analysis employing High-Performance Liquid Chromatography (HPLC).
- IUPAC
- PITC
Peptide Sequencing
Phenyl isothiocyanate is a critical reagent in the Edman degradation process, enabling the sequential removal and identification of amino acids from the N-terminus of a peptide chain.
Amino Acid Analysis
It serves as a derivatising agent for amino acids, facilitating their detection and quantification using High-Performance Liquid Chromatography (HPLC) techniques.
Organic Synthesis
As an organic building block, Phenyl isothiocyanate is employed in various synthetic pathways to introduce the isothiocyanate functional group into more complex molecules.
| Molecular weight | 135.19 |
|---|---|
| Linear formula | C6H5NCS |
| Assay | 99% |
| Boiling point | 218 °C(lit.)221 °C |
| Density | 1.132 g/mL at 20 °C(lit.) |
| Refractive index | n20/D 1.6515(lit.) |
| Concentration | 5% in heptane |
| Melting point | −21 °C(lit.) |
| Storage temperature | 2-8°C |
| Impurities tested | ≤0.01% water |
| Application | Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC. |
Hazard statements
- H301Toxic if swallowed
- H314Causes severe skin burns and eye damage
- H317May cause an allergic skin reaction
- H334May cause allergy or asthma symptoms if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 88 °C / 190.4 °F |
| Transport (UN / ADR) | UN 2927 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 25-34-42/43-51/53 |
| Safety statements (S) | 23-26-36/37/39-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Phenyl isothiocyanate used for?
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Phenyl isothiocyanate is predominantly used as a derivatising reagent for primary and secondary amines, notably in peptide sequencing via Edman degradation and in amino acid analyses by HPLC.
What is the CAS number and chemical formula for Phenyl isothiocyanate?
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The CAS number for Phenyl isothiocyanate is 103-72-0, and its chemical formula is C6H5NCS.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Phenyl isothiocyanate with an assay of 99%. This product is not represented as USP, BP, EP, or other pharmacopoeia grades.
What are the safety considerations for handling Phenyl isothiocyanate?
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Phenyl isothiocyanate is classified as Danger, with hazards including H301 (Toxic if swallowed), H314 (Causes severe skin burns and eye damage), H317 (May cause an allergic skin reaction), and H334 (May cause allergy or asthma symptoms or breathing difficulties if inhaled). Appropriate personal protective equipment, including gloves, goggles, and respiratory protection, is essential.
How is Phenyl isothiocyanate packed, shipped, and exported?
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Tech Serve Solutions packs, ships, and exports chemicals in compliance with all relevant international regulations, ensuring safe transit and handling.
How can I request a sample or quote for Phenyl isothiocyanate?
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To request a sample or a quotation for Phenyl isothiocyanate, please contact the TSS sales team through our website or direct contact details.
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