2-(Aminomethyl)piperidine
2-(Aminomethyl)piperidine (CAS: 22990-77-8, Formula: C6H14N2) is a versatile heterocyclic amine with a molecular weight of 114.19 g/mol. This compound serves as a key building block in organic synthesis. Its primary applications include use as a reactant for reversible aminal formation and in the synthesis of complex molecules such as N-heterocyclic carbene ligands and various pharmaceutical receptor antagonists. It is supplied by TSS with an assay of 97%.
- IUPAC
- (RS)-1-(Piperidin-2-yl)methanamine,2-Piperidinemethanamine
Reversible Aminal Formation
2-(Aminomethyl)piperidine functions as a reactant in the formation of reversible aminals, a useful transformation in organic synthesis for protecting amine groups or creating dynamic covalent systems.
Synthesis of N-Heterocyclic Carbene Ligands
This compound is employed in the synthesis of annulated N-heterocyclic carbene (NHC) ligands. NHCs are important in modern catalysis, particularly in cross-coupling reactions and organocatalysis.
Development of Muscarinic Receptor Antagonists
It serves as a precursor in the synthesis pathways for M3 muscarinic receptor antagonists. These compounds are investigated for potential therapeutic applications in various conditions.
Selective 5-HT5A Receptor Antagonists
2-(Aminomethyl)piperidine is utilised in the preparation of selective 5-HT5A receptor antagonists, which are subjects of research for neurological and psychiatric disorders.
Synthesis of Platinum(II) Complexes
The compound is used in the synthesis of ternary platinum(II) complexes, potentially exploring their applications in materials science or medicinal chemistry.
| Molecular weight | 114.19 |
|---|---|
| Empirical formula | C6H14N2 |
| Assay | 97% |
| Density | 0.9406 g/mL at 25 °C |
| Refractive index | n20/D 1.4854 |
| Application | Reactant for reversible aminal formation1Reactant for synthesis of:• Annulated N-heterocyclic carbene ligands2• M3 Muscarinic receptor antagonists3• Selective 5-ht5A receptor antagonists4• Ternary platinum(II) complexes5 |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 68 °C / 154.4 °F |
| Transport (UN / ADR) | UN 2735PSN1 8 / PGII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(Aminomethyl)piperidine used for?
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2-(Aminomethyl)piperidine is used as a reactant for reversible aminal formation and in the synthesis of N-heterocyclic carbene ligands, M3 muscarinic receptor antagonists, selective 5-HT5A receptor antagonists, and ternary platinum(II) complexes.
What are the CAS number and formula for 2-(Aminomethyl)piperidine?
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The CAS number is 22990-77-8, and the empirical formula (Hill notation) is C6H14N2.
What grade and purity does Tech Serve Solutions supply for 2-(Aminomethyl)piperidine?
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Tech Serve Solutions supplies 2-(Aminomethyl)piperidine with an assay of 97%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the primary safety hazards associated with 2-(Aminomethyl)piperidine?
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2-(Aminomethyl)piperidine is classified as Danger, with hazard statement H314, indicating it causes severe skin burns and eye damage. Appropriate personal protective equipment, including face shields, gloves, and suitable respirators, is mandatory during handling.
How is 2-(Aminomethyl)piperidine packed, shipped, and exported by TSS?
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2-(Aminomethyl)piperidine is packed and shipped according to UN 2735 specifications (Class 8, Packing Group II). TSS is a specialist global supplier and exporter of fine chemicals, facilitating international distribution.
How can I request a quote or sample of 2-(Aminomethyl)piperidine?
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To request a quote or sample of 2-(Aminomethyl)piperidine, please contact the TSS sales department via our website or by telephone.
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