2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate

CAS 287381-46-8ClCOOCH2CH(C6H3C(CH3)3)2Chemical Synthesis

2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate (CAS: 287381-46-8) is a specialised organic compound with a molecular weight of 370.91 g/mol. This acid halide serves as a valuable building block in organic synthesis, particularly in the preparation of protected amino acids and peptides. Its chemical structure lends itself to applications requiring specific derivatisation and controlled reactions within research and development settings.

Synonyms: 2,7-Di-tert-butyl-9-fluorenylmethyl chloroformateClCOOCH2CH(C6H3C(CH3)3)2

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2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate (ClCOOCH2CH(C6H3C(CH3)3)2) — chemical structure, CAS 287381-46-8; Chemistry, fine chemical supplied by Tech Serve Solutions

Acid HalidesBuilding BlocksCarbonyl CompoundsChemical SynthesisOrganic Building Blocks

01 /Applications

Peptide Synthesis Reagent

This chloroformate is employed as a protecting group reagent in solid-phase and solution-phase peptide synthesis. It facilitates the introduction of the 9-fluorenylmethyloxycarbonyl (Fmoc) group, a widely used temporary amine protecting group in peptide chemistry.

Organic Synthesis Building Block

As a versatile building block, it is utilised in the construction of complex organic molecules. Its reactive chloroformate moiety allows for facile derivatisation and functionalisation in multi-step synthetic pathways.

Research and Development

Primarily used in academic and industrial research laboratories, this compound aids in the exploration of novel synthetic methodologies and the development of new chemical entities requiring specific functional group manipulation.

02 /Properties

Molecular weight	370.91
Linear formula	ClCOOCH2CH(C6H3C(CH3)3)2
Assay	97%
Storage temperature	2-8°C
Melting point	66-70 °C(lit.)

03 /Safety & handling

GHS hazard pictogram: Corrosive (GHS05) — Corrosive

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves, clothing and eye/face protection
P305IF IN EYES
P310Immediately call a POISON CENTER or doctor

Protective equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Transport (UN / ADR)	UN 3261 8 / PGII
Water hazard class (WGK, DE)	3
Hazard codes (EU)	C
Risk statements (R)	34
Safety statements (S)	26-36/37/39-45

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

287381-46-8

MDL number

MFCD03701519

PubChem substance

24879152

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate used for?

2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate is primarily used as a reagent in peptide synthesis for introducing the Fmoc protecting group, and as a versatile building block in general organic synthesis for research and development purposes.

What is the CAS number and formula for 2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate?

The CAS number is 287381-46-8. The linear formula is ClCOOCH₂CH(C₆H₃C(CH₃)₃)₂.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate with a minimum purity of 97% (Assay). This product is intended for research and chemical synthesis use and is not supplied as USP, EP, BP, or any other pharmacopoeia grade.

How should 2,7-Di-tert-butyl-9-fluorenylmethyl chloroformate be handled safely?

This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection (type N100 or P3 filter). Store at 2-8°C.