2,4,6-Trimethylphenylboronic acid

CAS 5980-97-2C6H2(CH3)3B(OH)2Chemical Synthesis

2,4,6-Trimethylphenylboronic acid (CAS 5980-97-2) is an organoboron compound with the molecular formula C6H2(CH3)3B(OH)2 and a molecular weight of 164.01 g/mol. As a trisubstituted aryl boronic acid, it serves as a valuable building block in organic synthesis. It is primarily employed as a reactant in various cross-coupling reactions, facilitating the formation of new carbon-carbon bonds in complex molecule construction.

IUPAC: 2,4,6-Trimethylbenzeneboronic acid,Mesitylene-2-boronic acid,NSC 157832
Synonyms: 5980-97-2C6H2(CH3)3B(OH)22,4,6-Trimethylbenzeneboronic acidMesitylene-2-boronic acidNSC 157832

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2,4,6-Trimethylphenylboronic acid (C6H2(CH3)3B(OH)2) — chemical structure, CAS 5980-97-2; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical SynthesisOrganometallic Reagents

01 /Applications

Cross-Coupling Reactions

This boronic acid is a key reactant in cross-coupling reactions, such as the Suzuki-Miyaura coupling. It facilitates the synthesis of complex organic molecules, including biphenyl arsine ligands.

Synthesis of Substituted Biphenyls

It participates in cross-coupling with various aryl halides, including 2,6-disubstituted bromoarenes, to form substituted biphenyl structures.

Addition Reactions

2,4,6-Trimethylphenylboronic acid is utilised in addition reactions to activate substrates like naphthyridine N-oxides and beta-aryloxyacrylates, enabling further functionalisation.

Organic Synthesis Intermediate

Its specific structure makes it a useful intermediate for introducing the 2,4,6-trimethylphenyl moiety into target molecules during multi-step syntheses.

02 /Properties

Molecular weight	164.01
Linear formula	C6H2(CH3)3B(OH)2
Application	Reactant involved in:• Cross-coupling with α-bromocarbonyl compounds1 or 2,6-disubstituted bromoarenes2• Suzuki-Miyaura coupling for synthesis of biphenyl arsine ligands3• Addition reactions to naphthyridine N-oxides4 or β-aryloxyacrylates5
Melting point	115-122 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

5980-97-2

MDL number

MFCD00236060

PubChem substance

24878598

Beilstein registry

2831927

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2,4,6-Trimethylphenylboronic acid used for?

2,4,6-Trimethylphenylboronic acid is used as a reactant in various organic synthesis applications, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling and addition reactions.

What is the CAS number and formula for 2,4,6-Trimethylphenylboronic acid?

The CAS number is 5980-97-2 and the linear formula is C6H2(CH3)3B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this chemical as a research or technical grade material. We do not represent it as meeting USP, BP, EP, or pharmacopoeia standards.

What are the safety considerations when handling 2,4,6-Trimethylphenylboronic acid?

Handle with appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter may be required. Please consult the Safety Data Sheet for comprehensive hazard information.

How is 2,4,6-Trimethylphenylboronic acid packed and shipped?

Tech Serve Solutions exports this chemical globally. Packaging is designed to maintain product integrity during transit. Please contact us for specific shipping details or to request a quote.

How can I request a sample or quote for 2,4,6-Trimethylphenylboronic acid?

You can request a sample or a detailed quote by contacting our sales department through the website or by calling our main office. Please reference CAS 5980-97-2.