2,4,6-Trifluoronitrobenzene
2,4,6-Trifluoronitrobenzene (CAS: 315-14-0) is a fluorinated aromatic compound with the molecular formula F₃C₆H₂NO₂ and a molecular weight of 177.08 g/mol. It serves as a valuable building block in organic synthesis, particularly in medicinal chemistry. Its unique structure allows for targeted derivatization, making it a key intermediate for creating more complex molecules.
- IUPAC
- 1,3,5-Trifluoro-2-nitrobenzene
- Synonyms
- 315-14-01,3,5-Trifluoro-2-nitrobenzeneF3C6H2NO2
Medicinal Chemistry Intermediates
2,4,6-Trifluoronitrobenzene is utilized in the synthesis of novel pharmaceutical agents. Its fluorinated nature can impart desirable pharmacokinetic properties to drug candidates.
Preparation of Anilines
This compound has been employed in the preparation of 4-methoxy-2,6-difluoroanilines. These derivatives are versatile building blocks in medicinal chemistry research and development.
Organic Synthesis
As a fluorinated aryl building block, 2,4,6-Trifluoronitrobenzene is a useful reagent for introducing trifluoronitrophenyl moieties into organic structures, enabling diverse chemical transformations.
| Molecular weight | 177.08 |
|---|---|
| Linear formula | F3C6H2NO2 |
| Assay | 98% |
| Boiling point | 182-185 °C(lit.) |
| Density | 1.514 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.477(lit.) |
| Application | 2,4,6-Trifluoronitrobenzene has been used in preparation of 4-methoxy-2,6-difluoroanilines, versatile building blocks in medicinal chemistry1. |
| Melting point | 3.5 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H319Causes serious eye irritation
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 78 °C / 172.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Trifluoronitrobenzene used for?
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2,4,6-Trifluoronitrobenzene is primarily used as a building block in organic synthesis, especially in medicinal chemistry for the preparation of complex molecules and fluorinated anilines.
What is the CAS number and formula for 2,4,6-Trifluoronitrobenzene?
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The CAS number is 315-14-0 and the linear formula is F₃C₆H₂NO₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4,6-Trifluoronitrobenzene with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How should 2,4,6-Trifluoronitrobenzene be handled safely?
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2,4,6-Trifluoronitrobenzene is a Warning substance (GHS07) that is harmful if swallowed, in contact with skin, or if inhaled, and causes skin and eye irritation. Appropriate personal protective equipment including eyeshields, face shield, gloves, and a suitable respirator must be used. Ensure good ventilation.
How is 2,4,6-Trifluoronitrobenzene packaged and exported?
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We ensure that all our chemicals are packaged securely and in compliance with international shipping regulations for safe global export.
How can I request a quote or sample of 2,4,6-Trifluoronitrobenzene?
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Please contact our sales team through the website or by phone to request a quote or a sample of 2,4,6-Trifluoronitrobenzene.
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