2,4,6-Trifluorobenzenesulfonyl chloride
2,4,6-Trifluorobenzenesulfonyl chloride (CAS: 220239-64-5), with the empirical formula C6H2ClF3O2S and a molecular weight of 230.59 g/mol, is a specialised fluorinated organic building block. This compound serves as a valuable reagent in organic synthesis, particularly for introducing the 2,4,6-trifluorobenzenesulfonyl group into various molecules. Its applications span research and development in areas requiring precisely functionalised aromatic compounds.
- Synonyms
- 220239-64-5C6H2ClF3O2S

Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of complex organic molecules. It enables the regioselective introduction of the trifluorobenzenesulfonyl moiety, a structural element found in advanced materials and pharmaceuticals.
Fluorinated Building Block
Serves as a versatile building block for creating novel fluorinated compounds. The presence of fluorine atoms can impart unique electronic and steric properties, influencing reactivity and molecular behaviour.
Reagent in Chemical Research
Employed in academic and industrial research laboratories for exploring new synthetic pathways and developing novel chemical entities. Its reactivity as a sulfonyl chloride makes it suitable for various functionalisation reactions.
| Molecular weight | 230.59 |
|---|---|
| Empirical formula | C6H2ClF3O2S |
| Assay | 97% |
| Density | 1.637 g/mL at 25 °C |
| Refractive index | n20/D 1.508 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Flash point | >110 °C / >230 °F |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Trifluorobenzenesulfonyl chloride used for?
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2,4,6-Trifluorobenzenesulfonyl chloride is primarily used as an intermediate in organic synthesis and as a fluorinated building block for creating novel chemical compounds in research and development.
What are the CAS number and formula for 2,4,6-Trifluorobenzenesulfonyl chloride?
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The CAS number is 220239-64-5, and the empirical formula is C6H2ClF3O2S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4,6-Trifluorobenzenesulfonyl chloride with an assay of 97%. We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should 2,4,6-Trifluorobenzenesulfonyl chloride be handled?
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This compound is corrosive and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including gloves, eye protection, and protective clothing. Ensure adequate ventilation. In case of contact, rinse immediately with plenty of water and seek medical advice. Keep away from incompatible materials.
Is 2,4,6-Trifluorobenzenesulfonyl chloride a controlled substance?
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The provided data does not indicate that 2,4,6-Trifluorobenzenesulfonyl chloride is a controlled substance.
How is 2,4,6-Trifluorobenzenesulfonyl chloride packed, shipped, or exported?
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As a specialist global supplier, Tech Serve Solutions adheres to all relevant regulations for the safe packing, shipping, and export of chemicals.
How can I request a quote or sample for 2,4,6-Trifluorobenzenesulfonyl chloride?
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Please contact our sales department via the website or phone to request a quote or a sample of 2,4,6-Trifluorobenzenesulfonyl chloride.
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