2,4,6-Trifluoroaniline
2,4,6-Trifluoroaniline (CAS: 363-81-5) is a fluorinated organic building block with the molecular formula C6H4F3N and a molecular weight of 147.10 g/mol. This compound serves as a valuable intermediate in organic synthesis, particularly in the preparation of more complex fluorinated molecules. It finds utility in the creation of various chemical entities, contributing to advancements in materials science and pharmaceutical research.
- Synonyms
- 363-81-5F3C6H2NH2
Synthesis of 3-nitro-2,4,6-trifluoroacetanilide
2,4,6-Trifluoroaniline is employed as a precursor in the synthesis of 3-nitro-2,4,6-trifluoroacetanilide. This reaction highlights its role in introducing trifluoroaniline moieties into organic structures for further derivatization.
Preparation of Substituted Ureas
The compound is utilised in the synthesis of a series of N′-phenyl-N-(1-phenyl cyclopentyl)-methyl ureas. This application showcases its versatility in constructing complex urea derivatives with potential biological activity.
Development of Fluorinated Pyridinones
2,4,6-Trifluoroaniline serves as a building block in the synthesis of 4-substituted 2,6-difluoro N-aryl pyridinones. This application demonstrates its importance in the creation of novel heterocyclic compounds.
| Molecular weight | 147.10 |
|---|---|
| Linear formula | F3C6H2NH2 |
| Assay | ≥97% |
| Boiling point | 57 °C/22 mmHg(lit.) |
| Application | 2,4,6-Trifluoroaniline was used in the synthesis of:• 3-nitro-2,4,6 -trifluoroacetanilide1• series of N′-phenyl-N-(1- phenyl cyclopentyl)-methyl ureas2• 4-substituted 2,6-difluoro N-aryl pyridinones3 |
| Melting point | 33-37 °C(lit.) |
Hazard statements
- H228Flammable solid
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 58 °C / 136.4 °F |
| Transport (UN / ADR) | UN 1325 4.1 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37-41 |
| Safety statements (S) | 26-39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,4,6-Trifluoroaniline used for?
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2,4,6-Trifluoroaniline is used as a chemical intermediate in the synthesis of various organic compounds, including substituted acetanilides, ureas, and pyridinones, particularly in research and development settings.
What is the CAS number and molecular formula for 2,4,6-Trifluoroaniline?
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The CAS number is 363-81-5 and the molecular formula is C6H4F3N (or F3C6H2NH2).
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,4,6-Trifluoroaniline with a minimum purity of 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 2,4,6-Trifluoroaniline be handled safely?
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2,4,6-Trifluoroaniline is a flammable solid and causes serious eye damage. It may also cause respiratory irritation. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a dust mask (e.g., N95). Ensure good ventilation and keep away from heat and ignition sources.
Is 2,4,6-Trifluoroaniline a controlled substance?
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Based on the provided data, there is no indication that 2,4,6-Trifluoroaniline is a controlled substance.
How is 2,4,6-Trifluoroaniline packed, shipped, and exported?
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2,4,6-Trifluoroaniline is shipped as a flammable solid (UN 1325, Class 4.1). TSS exports globally, adhering to all relevant shipping and customs regulations for hazardous materials.
How can I request a sample or quote for 2,4,6-Trifluoroaniline?
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Please contact our sales department via our website or direct email to request a sample or obtain a quotation for 2,4,6-Trifluoroaniline.
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