2,4,5-Trimethylphenylboronic acid

CAS 352534-80-6C6H2(CH3)3B(OH)2Chemical Synthesis

2,4,5-Trimethylphenylboronic acid (CAS 352534-80-6) is an aryl boronic acid derivative with the linear formula C6H2(CH3)3B(OH)2 and a molecular weight of 164.01 g/mol. This compound serves as a key reactant in organic synthesis. It is primarily utilised in the preparation of complex organic molecules, including the synthesis of aryl-substituted cycloalkenecarboxylic acid methyl esters with potential affinity for human dopamine transporters and in modified Ullmann reactions.

Synonyms: 352534-80-6, C6H2(CH3)3B(OH)2

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2,4,5-Trimethylphenylboronic acid (C6H2(CH3)3B(OH)2) — chemical structure, CAS 352534-80-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Aryl Boronic AcidsBoronic AcidsChemical SynthesisOrganometallic Reagents

01 /Applications

Preparation of Aryl-Substituted Cycloalkenecarboxylic Acid Esters

Serves as a crucial reactant in synthesising specific aryl-substituted cycloalkenecarboxylic acid methyl esters. These compounds have been investigated for their affinity towards the human dopamine transporter.

Chan-Lam-Evans Coupling Reactions

Utilised in modified Chan-Lam-Evans coupling reactions, specifically in conjunction with nucleobases. This application facilitates the formation of new carbon-nitrogen bonds.

Organometallic Reagent in Synthesis

Functions as an organometallic reagent in advanced chemical synthesis. Its boronic acid functionality enables participation in various cross-coupling reactions.

02 /Properties

Molecular weight	164.01
Linear formula	C6H2(CH3)3B(OH)2
Application	Reactant for:• Preparation of aryl-substituted cycloalkenecarboxylic acid Me esters with affinity for human dopamine transporter1• Chan-Lam-Evans-modified Ullmann reaction with nucleobases2
Melting point	180-190 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

352534-80-6

MDL number

MFCD03427049

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 2,4,5-Trimethylphenylboronic acid used for?

2,4,5-Trimethylphenylboronic acid is used as a reactant in organic synthesis, notably for preparing aryl-substituted cycloalkenecarboxylic acid methyl esters and in modified Chan-Lam-Evans coupling reactions with nucleobases.

What are the CAS number and formula for 2,4,5-Trimethylphenylboronic acid?

The CAS number is 352534-80-6, and its linear formula is C6H2(CH3)3B(OH)2.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this compound for research and chemical synthesis purposes. The specific assay and grade are available upon request. TSS does not represent this product as USP, BP, or EP grade.

What are the safety considerations for handling 2,4,5-Trimethylphenylboronic acid?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. The compound has a WGK Germany rating of 3.