2,3-Naphthalenedicarboxaldehyde
2,3-Naphthalenedicarboxaldehyde (CAS 7149-49-7), with the molecular formula C₁₀H₆(CHO)₂, is a chemical compound utilised for its fluorescent properties. It serves as a valuable fluorogenic derivatizing agent, particularly for amines. Conjugates formed with this reagent exhibit enhanced stability and stronger fluorescence compared to those derived from other common reagents, making it a useful tool in analytical chemistry.
- IUPAC
- NDA
- Synonyms
- C10H6(CHO)2
Fluorogenic Derivatisation of Amines
2,3-Naphthalenedicarboxaldehyde is employed as a reagent for the sensitive detection and quantification of primary amines through fluorescence. It reacts with amines to form stable, highly fluorescent derivatives, enabling detection at low concentrations.
Analytical Chemistry Reagent
This compound is utilised in analytical laboratories for applications requiring fluorescent labelling. Its properties make it suitable for use in techniques like High-Performance Liquid Chromatography (HPLC) for the analysis of amine-containing samples.
Fluorescent Probes and Labels
The fluorescent characteristics of its derivatives make 2,3-Naphthalenedicarboxaldehyde a useful building block or reagent in the development of fluorescent probes and labels for biological and chemical research.
| Molecular weight | 184.19 |
|---|---|
| Linear formula | C10H6(CHO)2 |
| Storage temperature | 2-8°C |
| Impurities tested | ≤2% mono- and dicarboxylic acid (1H-NMR) |
| Application | Fluorogenic derivatizing agent for amines. NDA conjugates are more stable with stronger fluorescence (λEx 420 nm, λEm 490 nm) than phthaldialdehyde (OPA) conjugates.1,2,3,4 |
| Suitability | suitable for fluorescence |
| Melting point | 131-133 °C(lit.)132-135 °C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Fluorescence | λex 420 nm; λem ~480 nm in 0.1 M borate pH 9.3 (after derivatization with glycine [~90 μM glycine, ~20 μM N-]) |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,3-Naphthalenedicarboxaldehyde used for?
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2,3-Naphthalenedicarboxaldehyde (CAS 7149-49-7) is primarily used as a fluorogenic derivatizing agent for amines, creating stable and strongly fluorescent conjugates suitable for analytical applications, especially in HPLC.
What are the CAS number and formula for 2,3-Naphthalenedicarboxaldehyde?
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The CAS number is 7149-49-7, and its linear formula is C₁₀H₆(CHO)₂. The molecular weight is 184.19 g/mol.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,3-Naphthalenedicarboxaldehyde with a purity of ≤2% mono- and dicarboxylic acid (1H-NMR). This is a research/technical grade product, and TSS does not represent it as USP, BP, or EP.
What are the safety and handling recommendations for 2,3-Naphthalenedicarboxaldehyde?
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This compound is classified as a GHS07 irritant (Warning). Hazards include skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Recommended personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Handle in a well-ventilated area and avoid inhalation of dust.
How is 2,3-Naphthalenedicarboxaldehyde packed, shipped, and exported?
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2,3-Naphthalenedicarboxaldehyde is typically stored at 2-8°C. TSS packs and exports chemicals in compliance with international shipping regulations, ensuring safe transit to our global customers.
How can I request a sample or quote for 2,3-Naphthalenedicarboxaldehyde?
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To request a sample or a quotation, please contact our sales team through the website or by phone. Provide the product name and CAS number (7149-49-7) for efficient processing.
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