2,2-Diethoxypropane
2,2-Diethoxypropane (CAS: 126-84-1) is a clear, colourless liquid with the molecular formula C7H16O2 and a molar mass of 132.20 g/mol. This organic compound, also known as acetone diethyl acetal, functions primarily as a protecting group in organic synthesis and as a versatile building block. Its applications span various chemical processes, contributing to the creation of more complex molecules. It is supplied by TSS with a typical assay of 97%.
- IUPAC
- Acetone diethyl acetal
- Synonyms
- (CH3)2C(OC2H5)2Acetone diethyl acetal

Protecting Group in Organic Synthesis
2,2-Diethoxypropane is widely employed to protect ketone functionalities, particularly acetone, during multi-step synthetic procedures. It reacts with diols under acidic catalysis to form acetals, effectively masking the carbonyl group from unwanted reactions. This protecting group can be readily removed under aqueous acidic conditions when no longer needed.
Reagent in Chemical Synthesis
As a reactive acetal, it serves as a useful intermediate and building block in the synthesis of various organic compounds. Its structure allows for incorporation into larger molecules, facilitating the construction of complex organic architectures.
Solvent and Reaction Medium
While not its primary use, 2,2-Diethoxypropane can act as a solvent or co-solvent in specific organic reactions due to its chemical nature and solubility properties. Its relatively low boiling point aids in ease of removal post-reaction.
| Molecular weight | 132.20 |
|---|---|
| Linear formula | (CH3)2C(OC2H5)2 |
| Assay | 97% |
| Boiling point | 116-117 °C(lit.) |
| Density | 0.82 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.389(lit.) |
| Storage temperature | 2-8°C |

Hazard statements
- H225Highly flammable liquid and vapour
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 8 °C / 46.4 °F |
| Transport (UN / ADR) | UN 3271 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F |
| Risk statements (R) | 11 |
| Safety statements (S) | 16-29-33 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2-Diethoxypropane used for?
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2,2-Diethoxypropane (CAS: 126-84-1) is primarily used as a protecting group for carbonyls in organic synthesis and as an organic building block for creating more complex molecules.
What is the CAS number and chemical formula for 2,2-Diethoxypropane?
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The CAS number for 2,2-Diethoxypropane is 126-84-1, and its linear formula is (CH3)2C(OC2H5)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,2-Diethoxypropane with a minimum assay of 97%. This is typically a technical or research grade chemical, and TSS does not represent it as USP, BP, or EP grade.
How should 2,2-Diethoxypropane be handled safely?
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2,2-Diethoxypropane is a highly flammable liquid (H225) with a low flash point of 8 °C. It requires handling in well-ventilated areas, away from ignition sources, and appropriate personal protective equipment including eyeshields and chemical-resistant gloves. Always refer to the Safety Data Sheet for detailed handling procedures.
How is 2,2-Diethoxypropane packed and shipped?
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2,2-Diethoxypropane is packed according to international regulations for flammable liquids and shipped globally by Tech Serve Solutions, adhering to all transport requirements, including UN 3271 classification.
How can I request a sample or quote for 2,2-Diethoxypropane?
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To request a sample or a quote for 2,2-Diethoxypropane, please contact the TSS sales department via our website or by phone, providing your specific requirements.
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