2-[2-(2-Chloroethoxy)ethoxy]ethanol
2-[2-(2-Chloroethoxy)ethoxy]ethanol (CAS 5197-62-6, Cl(CH2CH2O)2CH2CH2OH) is a versatile chemical building block with a molecular weight of 168.62. This compound, featuring a terminal hydroxyl group and a chloroethoxyethoxy chain, serves as a key intermediate in organic synthesis. It is utilised in the preparation of complex molecules, including modified oligonucleotides and functionalised indole derivatives, making it valuable for research and development in various chemical sectors.
- IUPAC
- Triethylene glycol monochlorohydrin
- Synonyms
- Triethylene glycol monochlorohydrin
![2-[2-(2-Chloroethoxy)ethoxy]ethanol (Cl(CH2CH2O)2CH2CH2OH) — chemical structure, CAS 5197-62-6; Chemistry, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F5197-62-6.png&w=3840&q=75)
Synthesis of Indole Derivatives
2-[2-(2-Chloroethoxy)ethoxy]ethanol has been employed as a starting material in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane. This application highlights its utility in constructing complex heterocyclic compounds.
Modification of Oligonucleotides
This chemical serves as a reagent in the synthesis of modified oligonucleotides. It facilitates the introduction of disulfide or thiol functionalities at the 3'-end, alongside other modifications at the 5'-end.
Organic Synthesis Intermediate
As an organic building block, 2-[2-(2-Chloroethoxy)ethoxy]ethanol is valuable for creating diverse molecular structures. Its bifunctional nature allows for participation in various coupling and derivatisation reactions within chemical synthesis.
| Molecular weight | 168.62 |
|---|---|
| Linear formula | Cl(CH2CH2O)2CH2CH2OH |
| Assay | 96% |
| Boiling point | 117-120 °C/5 mmHg(lit.) |
| Density | 1.16 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.458(lit.) |
| Application | 2-[2-(2-Chloroethoxy)ethoxy]ethanol was used in the synthesis of 1-[3-(2-aminoethyl)-1H-indol-5-yloxy]-3,6-dioxa-8-mercaptooctane1. It was also used in the synthesis of modified oligonucleotides bearing a disulfide or a thiol function at the 3′-end and other modifications at the 5′-end2. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 107 °C / 224.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-[2-(2-Chloroethoxy)ethoxy]ethanol used for?
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2-[2-(2-Chloroethoxy)ethoxy]ethanol is used as an intermediate in organic synthesis, particularly for preparing functionalised indole derivatives and modified oligonucleotides.
What are the CAS number and formula for 2-[2-(2-Chloroethoxy)ethoxy]ethanol?
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The CAS number is 5197-62-6 and the linear formula is Cl(CH2CH2O)2CH2CH2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2-[2-(2-Chloroethoxy)ethoxy]ethanol with a minimum assay of 96%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations for handling 2-[2-(2-Chloroethoxy)ethoxy]ethanol?
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This compound is a Warning substance, identified by GHS07. It causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Appropriate personal protective equipment, including eyeshields and gloves, should be used, and a suitable respirator employed when handling.
How is 2-[2-(2-Chloroethoxy)ethoxy]ethanol shipped and exported?
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Tech Serve Solutions is a global supplier and exporter of chemicals, adhering to all relevant shipping and export regulations for compounds like 2-[2-(2-Chloroethoxy)ethoxy]ethanol.
How can I request a quote or sample?
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To request a quote or obtain a sample of 2-[2-(2-Chloroethoxy)ethoxy]ethanol, please contact our sales team through the TSS website.
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