2-(1-Piperazinyl)acetic acid monohydrate
2-(1-Piperazinyl)acetic acid monohydrate (CAS: 667462-09-1) is a heterocyclic compound with the molecular formula C6H12N2O2 · H2O and a molecular weight of 162.19 g/mol. This white to off-white solid functions as a versatile building block in chemical synthesis and chemical biology. Its piperazine ring and acetic acid moiety make it valuable for constructing more complex molecules, particularly in the fields of peptide chemistry and the development of unnatural amino acid derivatives.
- IUPAC
- 1-Piperazineacetic acid monohydrate,Piperazinoacetic acid monohydrate
- Synonyms
- 1-Piperazineacetic acid monohydratePiperazinoacetic acid monohydrate

Chemical Synthesis Intermediate
Serves as a key intermediate in the synthesis of diverse organic compounds. Its structural features allow for various derivatizations, facilitating the creation of novel molecular architectures.
Peptide Chemistry
Utilised in peptide synthesis for incorporating unnatural amino acid derivatives. This contributes to the development of modified peptides with altered or enhanced properties for research purposes.
Drug Discovery Building Block
Acts as a scaffold in medicinal chemistry for the design and synthesis of potential pharmaceutical agents. Its heterocyclic nature is often found in bioactive molecules.
Chemical Biology Research
Employed in chemical biology for constructing probes or labelled molecules to investigate biological processes. It aids in understanding complex biological systems at a molecular level.
| Molecular weight | 162.19 |
|---|---|
| Empirical formula | C6H12N2O2 · H2O |
| Assay | ≥97% (TLC) |


Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H315Causes skin irritation
- H318Causes serious eye damage
- H332Harmful if inhaled
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Water hazard class (WGK, DE) | 3 |
|---|---|
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2-(1-Piperazinyl)acetic acid monohydrate used for?
+
It is primarily used as a building block in chemical synthesis, peptide chemistry, drug discovery, and chemical biology research.
What is the CAS number and formula for 2-(1-Piperazinyl)acetic acid monohydrate?
+
The CAS number is 667462-09-1 and the empirical formula is C6H12N2O2 · H2O.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this compound with an assay of ≥97% (TLC). This product is intended for research and laboratory use and is not supplied as USP, BP, EP, or any other pharmacopoeia grade.
How should 2-(1-Piperazinyl)acetic acid monohydrate be handled safely?
+
This compound is classified as dangerous. It is harmful if swallowed, in contact with skin, or if inhaled. It causes skin irritation, serious eye damage, and may cause respiratory irritation. Handle with appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, in a well-ventilated area.
Is this chemical packed and shipped internationally by TSS?
+
Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and can arrange for packing and shipping to customers worldwide.
How can I request a quote or sample?
+
To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number.
▶ Related products

1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis

1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more

3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis

3-Methyl-1,5-pentanediol
Chemical Synthesis

3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis