17-(Allylamino)-17-demethoxygeldanamycin
17-(Allylamino)-17-demethoxygeldanamycin (CAS: 75747-14-7; Formula: C31H43N3O8; MW: 585.69) is a potent inhibitor of heat shock protein 90 (Hsp90) and oncogenic proteins. This compound, supplied by Tech Serve Solutions, also induces apoptosis and demonstrates anti-tumour effects, making it a valuable tool in cancer research and cell biology studies.
- IUPAC
- 17-(Allylamino)geldanamycin,17-Demethoxy-17-allylamino geldanamycin,17-AAG,CP 127374,Geldanamycin,17-demethoxy-17-(2-propenylamino)-,NSC 330507,Tanespimycin
- Synonyms
- 17-(Allylamino)geldanamycin17-Demethoxy-17-allylamino geldanamycin17-AAGCP 127374NSC 330507Tanespimycin
Hsp90 Inhibition
17-(Allylamino)-17-demethoxygeldanamycin functions by inhibiting heat shock protein 90 (Hsp90). This inhibition impacts the stability and activity of numerous client proteins involved in cell cycle regulation and signalling pathways.
Oncogenic Protein Modulation
This compound targets the expression of heat shock factor-1 and inhibits the activity of key oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185<sup>erB2</sup>, contributing to its anti-tumour potential.
Apoptosis Induction
Beyond its inhibitory actions, 17-(Allylamino)-17-demethoxygeldanamycin is known to actively induce apoptosis, a programmed cell death mechanism crucial for eliminating abnormal or cancerous cells.
Cancer Research
Due to its multifaceted mechanism of action, including Hsp90 inhibition and apoptosis induction, 17-AAG is widely utilized in preclinical cancer research to explore novel therapeutic strategies.
| Molecular weight | 585.69 |
|---|---|
| Empirical formula | C31H43N3O8 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | DMSO: solublemethanol: soluble |
| Storage temperature | −20°C |
| Application | 17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis. |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 17-(Allylamino)-17-demethoxygeldanamycin used for?
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17-(Allylamino)-17-demethoxygeldanamycin is primarily used as a research chemical for its ability to inhibit heat shock protein 90 (Hsp90), modulate oncogenic proteins, and induce apoptosis, making it valuable in cancer research and cell biology studies.
What is the CAS number and molecular formula for 17-(Allylamino)-17-demethoxygeldanamycin?
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The CAS number is 75747-14-7 and the molecular formula is C31H43N3O8.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 17-(Allylamino)-17-demethoxygeldanamycin with an assay of ≥98% (HPLC). This is a research grade chemical and not intended for human or veterinary use, nor is it represented as USP, BP, EP, or pharmacopoeia grade.
How should 17-(Allylamino)-17-demethoxygeldanamycin be handled safely?
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Appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter, should be used when handling this compound. It is classified under WGK Germany 3.
How is 17-(Allylamino)-17-demethoxygeldanamycin shipped?
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This product is shipped under wet ice to maintain its stability during transit.
How can I request a quote or sample for 17-(Allylamino)-17-demethoxygeldanamycin?
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Please contact our sales team via the website or direct inquiry channels to request a quote or sample.
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