1-(Trimethylsilyl)propyne
1-(Trimethylsilyl)propyne (CAS 6224-91-5) is an organosilicon compound with the linear formula CH3C≡CSi(CH3)3 and a molar mass of 112.24 g/mol. This flammable liquid serves as a valuable building block in organic synthesis. It is predominantly utilised in the creation of complex organic molecules, including substituted indenes and indenones through various metal-catalyzed reactions, making it a key reagent in advanced chemical research and development.
- IUPAC
- Trimethyl-1-propynylsilane
- Synonyms
- Trimethyl-1-propynylsilane
Synthesis of Substituted Indenes
1-(Trimethylsilyl)propyne is employed in palladium-catalyzed carboannulation reactions for the synthesis of highly substituted indenes. This application highlights its utility in constructing complex polycyclic aromatic systems.
Preparation of Indenones
This compound participates in rhodium-catalyzed reactions with 2-bromophenylboronic acids to yield indenones. This method provides a route to functionalized indenone structures.
Organic Building Block
As a versatile organic building block, 1-(Trimethylsilyl)propyne is used in various chemical synthesis pathways. Its unique structure allows for the introduction of specific functionalities in organic molecules.
| Molecular weight | 112.24 |
|---|---|
| Linear formula | CH3C≡CSi(CH3)3 |
| Assay | 99% |
| Boiling point | 99-100 °C(lit.) |
| Density | 0.758 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.417(lit.) |
| Vapour density | >1 (vs air) |
| Storage temperature | 2-8°C |
| Application | 1-(Trimethylsilyl)propyne was used in the synthesis of highly substituted indenes via palladium-catalyzed carboannulation1 and indenones via a rhodium-catalyzed reaction with 2-bromophenylboronic acids2. |
Hazard statements
- H225Highly flammable liquid and vapour
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 4 °C / 39.2 °F |
| Transport (UN / ADR) | UN 1993BF 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xi |
| Risk statements (R) | 11-36/37/38 |
| Safety statements (S) | 16-26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-(Trimethylsilyl)propyne primarily used for?
+
1-(Trimethylsilyl)propyne is primarily used as a building block in organic synthesis, notably in the preparation of substituted indenes and indenones via metal-catalyzed reactions.
What is the CAS number and formula for 1-(Trimethylsilyl)propyne?
+
The CAS number is 6224-91-5 and the linear formula is CH3C≡CSi(CH3)3.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies 1-(Trimethylsilyl)propyne with a purity of 99%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the main safety considerations when handling 1-(Trimethylsilyl)propyne?
+
1-(Trimethylsilyl)propyne is a highly flammable liquid (Flash Point 4 °C) and can cause skin, eye, and respiratory irritation. It is essential to handle it with appropriate personal protective equipment, including safety goggles, gloves, and in a well-ventilated area, away from ignition sources.
How is 1-(Trimethylsilyl)propyne packed, shipped, and exported?
+
1-(Trimethylsilyl)propyne is shipped as a flammable liquid, UN 1993, Packing Group II. Storage is recommended at 2-8°C. Tech Serve Solutions handles global export of this chemical reagent.
How can I request a sample or a quote for 1-(Trimethylsilyl)propyne?
+
To request a sample or a quote, please contact our sales team through the website or by direct inquiry, providing your contact details and intended use.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis