1-Propargyl-1H-benzotriazole
1-Propargyl-1H-benzotriazole (CAS: 142321-23-1, Formula: C9H7N3) is a valuable organic compound with a molecular weight of 157.17 g/mol. It functions as a key reactant in various synthetic transformations, notably in C-C bond formation and the synthesis of complex molecules. Its utility spans across chemical synthesis, serving as a versatile building block for advanced chemical research and development, including the creation of potential antibacterial agents.
- IUPAC
- 1-(2-Propynyl)-1H-benzotriazole
Preparation of Antibacterial Agents
1-Propargyl-1H-benzotriazole serves as a reactant in the preparation of clarithromycin analogs. This application leverages click chemistry to develop novel antibacterial agents.
Sonogashira Coupling Reactions
This compound is employed as a reactant in Sonogashira coupling reactions, a fundamental process for forming carbon-carbon bonds between terminal alkynes and aryl or vinyl halides.
Bronsted Superacid-Catalyzed Reactions
It acts as a reactant in processes mediated by Bronsted superacids, showcasing its utility in advanced organic synthesis where strong acidic conditions are required.
Hydroboration and Hydrostannylation
1-Propargyl-1H-benzotriazole is utilised as a reactant in hydroboration and hydrostannylation reactions, which are important for introducing boron and tin functionalities into organic molecules.
| Molecular weight | 157.17 |
|---|---|
| Empirical formula | C9H7N3 |
| Assay | 96% |
| Application | Reactant for:• Preparation of clarithromycin analogs via click chemistry as antibacterial agents1• Sonogashira coupling2• Bronsted superacid-catalyzed reactions3• Hydroboration and hydrostannylation reactions4 |
| Melting point | 52-56 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Propargyl-1H-benzotriazole used for?
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1-Propargyl-1H-benzotriazole is used as a reactant in chemical synthesis, including preparations for clarithromycin analogs, Sonogashira coupling, Bronsted superacid-catalyzed reactions, and hydroboration/hydrostannylation reactions.
What is the CAS number and formula for 1-Propargyl-1H-benzotriazole?
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The CAS number is 142321-23-1, and its empirical formula is C9H7N3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Propargyl-1H-benzotriazole with an assay of 96%. TSS does not represent this product as USP, BP, or EP grade.
How should 1-Propargyl-1H-benzotriazole be handled?
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Handle 1-Propargyl-1H-benzotriazole with appropriate personal protective equipment, including a dust mask (type N95 US), eyeshields, and gloves. Ensure good ventilation to avoid inhalation of dust (H335).
Is 1-Propargyl-1H-benzotriazole subject to any special regulations?
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Based on the provided data, 1-Propargyl-1H-benzotriazole is classified as an irritant (H315, H319, H335) with hazard codes Xi. It is not indicated as a controlled substance.
How is 1-Propargyl-1H-benzotriazole supplied and exported?
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1-Propargyl-1H-benzotriazole is available from Tech Serve Solutions, a global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents.
How can I request a quote or sample?
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To request a quote or sample of 1-Propargyl-1H-benzotriazole, please contact the Tech Serve Solutions sales team through our website or designated contact channels.
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