1-Methyl-2-piperidinemethanol
1-Methyl-2-piperidinemethanol (CAS: 20845-34-5; Formula: C7H15NO; MW: 129.20 g/mol) is a heterocyclic organic compound. This piperidine derivative serves as a valuable building block in chemical synthesis, particularly for the development of complex pharmaceutical agents and research chemicals. Its structure allows for diverse reactions, making it a versatile intermediate for creating novel molecules with specific biological activities and applications in medicinal chemistry.
- IUPAC
- 2-Hydroxymethyl-1-methylpiperidine,NSC 45464
Synthesis of Selective MCH1R Antagonists
This compound acts as a key reactant in the synthesis of selective Mas-related G protein-coupled receptor X1 (MCH1R) antagonists, which are investigated for various therapeutic applications.
Development of GnRH Receptor Antagonists
It is utilised as a building block in the preparation of human Gonadotropin-releasing Hormone (GnRH) receptor antagonists, targets for hormonal therapies.
Inhibitor Synthesis for VEGFR/FGFR
1-Methyl-2-piperidinemethanol is employed in the synthesis of dual inhibitors targeting vascular endothelial growth factor receptor-2 (VEGFR-2) and fibroblast growth factor receptor 1 (FGFR1).
Preparation of Imaging Agents
This chemical is a precursor for radioiodinatable brain imaging agents designed for studying the CB1 cannabinoid receptor.
GABAA Receptor Agonist Development
It serves as a reactant in the synthesis of GABAA receptor agonists, specifically targeting the alpha-3 subunit.
Carbamate and Imidazole Synthesis
The compound is used in reactions with carbonyldiimidazoles to form carbamates and N-alkylimidazoles, demonstrating its utility in broader organic synthesis.
| Molecular weight | 129.20 |
|---|---|
| Empirical formula | C7H15NO |
| Assay | 98% |
| Boiling point | 79-80 °C/7 mmHg(lit.) |
| Density | 0.984 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4823(lit.) |
| Application | Reactant for synthesis of: Selective MCH1R antagonists1 Human GnRH receptor antagonists2 Dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor 1 inhibitors3 Radioiodinatable brain imaging agents for CB1 cannabinoid receptor4 GABAA receptor agonists at the α3 subunit5 Carbamates and N-alkylimidazoles from reaction of carbonyldiimidazoles with alcohols6 |
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 81 °C / 177.8 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Methyl-2-piperidinemethanol used for?
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1-Methyl-2-piperidinemethanol is primarily used as a building block and reactant in chemical synthesis, especially for developing pharmaceutical agents such as selective MCH1R antagonists, human GnRH receptor antagonists, dual VEGFR/FGFR inhibitors, brain imaging agents, and GABAA receptor agonists.
What is the CAS number and formula for 1-Methyl-2-piperidinemethanol?
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The CAS number for 1-Methyl-2-piperidinemethanol is 20845-34-5, and its empirical formula is C7H15NO.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Methyl-2-piperidinemethanol with an assay of 98%. This product is typically considered a research or technical grade and is not represented as USP, BP, or EP.
How should 1-Methyl-2-piperidinemethanol be handled safely?
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Handling requires appropriate personal protective equipment, including eyeshields and gloves. A full-face or multi-purpose respirator is recommended. It is classified under NA 1993 / PGIII with a WGK Germany rating of 3, indicating it is hazardous.
Is 1-Methyl-2-piperidinemethanol a controlled substance?
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The provided data does not indicate that 1-Methyl-2-piperidinemethanol is a controlled substance.
How is 1-Methyl-2-piperidinemethanol packed and exported?
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1-Methyl-2-piperidinemethanol is carefully packed according to relevant regulations for safe transport and export. Specific packaging details are available upon request.
How can I request a quote or sample?
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To request a quote or a sample of 1-Methyl-2-piperidinemethanol, please contact the Tech Serve Solutions sales team through our website or by phone.
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