1-Hydroxybenzotriazole hydrate
1-Hydroxybenzotriazole hydrate (CAS: 123333-53-9) is a white to off-white powder supplied in synthesis grade with an assay of 97%. This compound, with a molecular weight of 135.12 g/mol on an anhydrous basis, is an essential additive in chemical synthesis. It is primarily utilised as an additive in oligonucleotide couplings and for facilitating racemization-free peptide couplings, making it a valuable reagent in peptide and oligonucleotide chemistry.
- IUPAC
- HOBt Hydrate
- Synonyms
- 1-Hydroxybenzotriazole hydrateHOBt Hydrate
Peptide Synthesis
1-Hydroxybenzotriazole hydrate is extensively employed as an additive in peptide coupling reactions. It aids in suppressing racemization, ensuring the stereochemical integrity of the synthesized peptide chains.
Oligonucleotide Synthesis
This compound serves as a crucial additive in the coupling steps during oligonucleotide synthesis. It enhances the efficiency and success rate of phosphoramidite couplings, contributing to the formation of accurate DNA and RNA sequences.
Active Ester Formation
As an additive in various coupling reactions, 1-Hydroxybenzotriazole hydrate can facilitate the formation of activated esters, which are key intermediates in organic synthesis.
| Molecular weight | 135.12 (anhydrous basis) |
|---|---|
| Empirical formula | C6H5N3O · xH2O |
| Assay | 97% |
| Application | Additive used in oligonucleotide couplings1,2 and in racemization-free peptide couplings.3,4 |
| Melting point | 155-158 °C(lit.) |
Hazard statements
- H228Flammable solid
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
| Transport (UN / ADR) | UN 3380 4.1/PG 1 |
|---|---|
| Water hazard class (WGK, DE) | nwg |
| Hazard codes (EU) | F |
| Risk statements (R) | 1-11-44 |
| Safety statements (S) | 26-37-60 |
| Supplemental hazards | Explosive when dry., Risk of explosion if heated under confinement. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality | synthesis grade |
|---|---|
| Description | White to Off White Powder |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Hydroxybenzotriazole hydrate used for?
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1-Hydroxybenzotriazole hydrate is primarily used as an additive in peptide coupling reactions to suppress racemization and in oligonucleotide couplings to enhance reaction efficiency.
What is the CAS number and formula for 1-Hydroxybenzotriazole hydrate?
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The CAS number for 1-Hydroxybenzotriazole hydrate is 123333-53-9. Its empirical formula is C6H5N3O · xH2O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Hydroxybenzotriazole hydrate in synthesis grade with an assay of 97%.
What are the safety considerations for handling 1-Hydroxybenzotriazole hydrate?
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1-Hydroxybenzotriazole hydrate is classified as flammable (H228) and carries supplemental hazards including risk of explosion if heated under confinement. It is explosive when dry. Always handle with appropriate personal protective equipment in a well-ventilated area, keeping it away from heat, sparks, and open flames.
How is 1-Hydroxybenzotriazole hydrate packed and exported?
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Tech Serve Solutions exports chemicals globally, ensuring appropriate packaging and compliance with international shipping regulations for hazardous materials like 1-Hydroxybenzotriazole hydrate (UN 3380).
How can I request a sample or quote for 1-Hydroxybenzotriazole hydrate?
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Please contact the Tech Serve Solutions sales team directly via our website or by phone to request a sample or a quotation for 1-Hydroxybenzotriazole hydrate.
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