1-Hydroxy-7-azabenzotriazole solution
1-Hydroxy-7-azabenzotriazole solution (CAS 39968-33-7), with the molecular formula C5H4N4O and a molecular weight of 136.11 g/mol, is supplied as approximately 0.6 M in DMF. This compound serves as a crucial additive and reagent in chemical synthesis, particularly in peptide chemistry. Its properties make it valuable for forming active esters, facilitating efficient coupling reactions in the creation of complex molecules.
- IUPAC
- 3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol,HOAt
- Synonyms
- HOAt3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol
Peptide Synthesis
1-Hydroxy-7-azabenzotriazole solution is extensively used as an additive in peptide coupling reactions. It enhances coupling efficiency and suppresses racemization, leading to higher yields and purer peptide products.
Active Ester Formation
This solution is employed in the formation of active esters, which are reactive intermediates used in various organic synthesis applications, including the construction of peptides and other complex organic molecules.
Chemical Biology
In chemical biology research, it acts as a versatile reagent for synthesizing modified peptides and other biomolecules, aiding in the study of biological processes and drug discovery.
General Organic Synthesis
Beyond peptide chemistry, 1-Hydroxy-7-azabenzotriazole solution is a useful reagent for a range of organic transformations requiring efficient coupling or activation steps.
| Molecular weight | 136.11 |
|---|---|
| Empirical formula | C5H4N4O |
| Density | 0.973 g/mL at 20 °C |
| Refractive index | n20/D 1.441 |
| Concentration | ~0.6 M in DMF |
| Impurities tested | <1.0% water |
Hazard statements
- H226Flammable liquid and vapour
- H302Harmful if swallowed
- H318Causes serious eye damage
- H360D
Precautionary statements
- P201Obtain special instructions before use
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 58 °C / 136.4 °F |
| Transport (UN / ADR) | UN 1993C 3 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 61-20/21-36 |
| Safety statements (S) | 53-26-36/37-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1-Hydroxy-7-azabenzotriazole solution used for?
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1-Hydroxy-7-azabenzotriazole solution is primarily used as an additive in peptide coupling reactions to enhance efficiency and suppress racemization, and in the formation of active esters for organic synthesis.
What are the CAS number and formula for 1-Hydroxy-7-azabenzotriazole solution?
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The CAS number is 39968-33-7 and the empirical formula is C5H4N4O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1-Hydroxy-7-azabenzotriazole solution at approximately 0.6 M in DMF. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the key safety concerns when handling this chemical?
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This solution is a flammable liquid and vapour (H226), harmful if swallowed, in contact with skin, or if inhaled (H302 + H312 + H332), and causes serious eye damage (H318). It may also damage the unborn child (H360D). Handle with appropriate personal protective equipment, including eye protection, gloves, and respiratory protection, in a well-ventilated area.
Is this product available for export?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals and laboratory reagents, including 1-Hydroxy-7-azabenzotriazole solution.
How can I request a quote or sample?
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Please contact our sales team directly via the website or your usual sales representative to request a quote or a sample of 1-Hydroxy-7-azabenzotriazole solution.
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